Epidemiology, pathophysiology and contemporary management of cardiogenic shock–a position statement from the Heart Failure Association of the European Society …

O Chioncel, J Parissis, A Mebazaa… - European journal of …, 2020 - Wiley Online Library
Cardiogenic shock (CS) is a complex multifactorial clinical syndrome with extremely high
mortality, developing as a continuum, and progressing from the initial insult (underlying …

Acute heart failure

M Arrigo, M Jessup, W Mullens, N Reza… - Nature Reviews …, 2020 - nature.com
Acute heart failure (AHF) is a syndrome defined as the new onset (de novo heart failure
(HF)) or worsening (acutely decompensated heart failure (ADHF)) of symptoms and signs of …

Heart failure: an update from the last years and a look at the near future

M Riccardi, AM Sammartino, M Piepoli… - ESC heart …, 2022 - Wiley Online Library
In the last years, major progress occurred in heart failure (HF) management. Quadruple
therapy is now mandatory for all the patients with HF with reduced ejection fraction. Whilst …

Biomarkers as prognostic predictors and therapeutic guide in critically ill patients: clinical evidence

R Méndez Hernández, F Ramasco Rueda - Journal of Personalized …, 2023 - mdpi.com
A biomarker is a molecule that can be measured in a biological sample in an objective,
systematic, and precise way, whose levels indicate whether a process is normal or …

Advances in the staging and phenotyping of cardiogenic shock: part 1 of 2

JC Jentzer, C Rayfield, S Soussi, DD Berg… - JACC: Advances, 2022 - jacc.org
Cardiogenic shock (CS) is a heterogeneous syndrome reflecting a broad spectrum of shock
severity, diverse etiologies, variable cardiac function, different hemodynamic trajectories …

Optimising clinical trials in acute myocardial infarction complicated by cardiogenic shock: a statement from the 2020 Critical Care Clinical Trialists Workshop

M Arrigo, S Price, DA Baran, J Pöss… - The Lancet …, 2021 - thelancet.com
Acute myocardial infarction complicated by cardiogenic shock (AMICS) is a critical syndrome
with a high risk of morbidity and mortality. Current management consists of coronary …

Circulating dipeptidyl peptidase 3 and alteration in haemodynamics in cardiogenic shock: results from the OptimaCC trial

K Takagi, A Blet, B Levy, B Deniau… - European journal of …, 2020 - Wiley Online Library
Abstract Aims Dipeptidyl peptidase 3 (DPP3) is a protease involved in the degradation of
cardiovascular mediators. Its administration has been shown to be associated with impaired …

Monitoring circulating dipeptidyl peptidase 3 (DPP3) predicts improvement of organ failure and survival in sepsis: a prospective observational multinational study

A Blet, B Deniau, K Santos, DPT van Lier, F Azibani… - Critical care, 2021 - Springer
Abstract Background Dipeptidyl peptidase 3 (DPP3) is a cytosolic enzyme involved in the
degradation of various cardiovascular and endorphin mediators. High levels of circulating …

The emerging role of dipeptidyl peptidase 3 in pathophysiology

G Malovan, B Hierzberger, S Suraci… - The FEBS …, 2023 - Wiley Online Library
Dipeptidyl peptidase 3 (DPP3), a zinc‐dependent aminopeptidase, is a highly conserved
enzyme among higher animals. The enzyme cleaves dipeptides from the N‐terminus of tetra …

Inhibition of circulating dipeptidyl-peptidase 3 restores cardiac function in a sepsis-induced model in rats: a proof of concept study

B Deniau, A Blet, K Santos, P Vaittinada Ayar… - PLoS …, 2020 - journals.plos.org
Sepsis is a global economic and health burden. Dipeptidyl peptidase 3 (DPP3) is elevated
in the plasma of septic patients. The highest levels of circulating DPP3 (cDPP3) are found in …