The use of antibiotics has enabled the successful treatment of bacterial infections, saving the
lives and improving the health of many patients worldwide. However, the emergence and …

Classically all vaccines were produced using live or attenuated microorganisms or parts of
them. However, the use of whole organisms, their components or the biological process for …

Streptococcus pyogenes, also known as group A Streptococcus (GAS), causes mild human
infections such as pharyngitis and impetigo and serious infections such as necrotizing …

Acute rheumatic fever is caused by an autoimmune response to throat infection with
Streptococcus pyogenes. Cardiac involvement during acute rheumatic fever can result in …

Abstract Group A Streptococcus (GAS; Streptococcus pyogenes) is a bacterial pathogen for
which a commercial vaccine for humans is not available. Employing the advantages of high …

Streptococcus pyogenes ranks among the main causes of mortality from bacterial infections
worldwide. Currently there is no vaccine to prevent diseases such as rheumatic heart …

Summary emm sequence typing is the most widely used method for defining group A
streptococcal (GAS) strains, and has been applied to isolates in all regions of the world. We …

Streptococcus pyogenes is an important global pathogen, causing considerable morbidity
and mortality, especially in low and middle income countries where rheumatic heart disease …

Preclinical antigen discovery, vaccine formulation, and efficacy studies in animal models
have progressed significantly in recent years. There is now a need to move promising …

Interaction of the M-protein of group A Streptococcus (GAS) with its numerous host binding
partners might assist the bacteria in evading host immune responses. Although the …