Despite the decline in death rate from breast cancer and recent advances in targeted
therapies and combinations for the treatment of metastatic disease, metastatic breast cancer …

Significance: During the past decades, thiosemicarbazones were clinically developed for a
variety of diseases, including tuberculosis, viral infections, malaria, and cancer. With regard …

The great success of cisplatin as a chemotherapeutic agent considerably increased
research efforts in inorganic biochemistry to identify more metallic drugs having the potential …

Currently, cancer and its progression to metastasis result in a large number of deaths. The
lack of new drugs, appropriate clinical trials for metastasis preventive drugs and incomplete …

Background Neuroblastoma is a relatively common and highly belligerent childhood tumor
with poor prognosis by current therapeutic approaches. A novel anti-cancer agent of the di-2 …

Copper is an essential trace metal required by organisms to perform a number of important
biological processes. Copper readily cycles between its reduced Cu (i) and oxidised Cu (ii) …

N-myc downstream regulated gene-1 (NDRG1) is a potent metastasis suppressor that is
regulated by hypoxia, metal ions including iron, the free radical nitric oxide (NO.), and …

Metastasis is currently the leading cause of cancer related death and is the most feared and
difficult to treat outcome for cancer patients. This complex process is regulated by a plethora …

N-myc-downregulated gene 1 (NDRG1) has potent anticancer effects and inhibits cell
growth, survival, metastasis, and angiogenesis. Previous studies suggested that NDRG1 is …

The metastasis suppressor, N-myc downstream-regulated gene-1 (NDRG1), plays
multifaceted roles in inhibiting oncogenic signaling and can suppress the epithelial …