Unraveling the epigenetic landscape of pulmonary arterial hypertension: implications for personalized medicine development

J Dave, V Jagana, R Janostiak, M Bisserier - Journal of Translational …, 2023 - Springer
Pulmonary arterial hypertension (PAH) is a multifactorial disease associated with the
remodeling of pulmonary blood vessels. If left unaddressed, PAH can lead to right heart …

Micro-RNA analysis in pulmonary arterial hypertension: current knowledge and challenges

CA Santos-Ferreira, MT Abreu, CI Marques… - Basic to Translational …, 2020 - jacc.org
Pulmonary arterial hypertension (PAH) is a rare, chronic disease of the pulmonary
vasculature that is associated with poor outcomes. Its pathogenesis is multifactorial and …

Mesenchymal stromal cells-derived exosomes alleviate ischemia/reperfusion injury in mouse lung by transporting anti-apoptotic miR-21-5p

J wei Li, L Wei, Z Han, Z Chen - European Journal of Pharmacology, 2019 - Elsevier
Abstract MiR-21-5p is an anti-apoptotic miRNA known to mediate the protective effect of
mesenchymal stromal cell-secreted exosomes (MSC-Exo) against oxidative stress-induced …

The m6A methyltransferase METTL3 promotes hypoxic pulmonary arterial hypertension

Y Qin, Y Qiao, L Li, E Luo, D Wang, Y Yao, C Tang… - Life sciences, 2021 - Elsevier
Abstract Aims N 6-methyladenosine (m 6 A) is the most prevalent internal chemical RNA
modification in mammal mRNAs. Accumulating evidence has shown the critical role of m 6 A …

[HTML][HTML] LncRNA-MTA2TR functions as a promoter in pancreatic cancer via driving deacetylation-dependent accumulation of HIF-1α

Z Zeng, F Xu, H Zheng, P Cheng, Q Chen, Z Ye… - Theranostics, 2019 - ncbi.nlm.nih.gov
Rationale: Hypoxia has been proved to contribute to aggressive phenotype of cancers, while
functional and regulatory mechanism of long noncoding RNA (lncRNA) in the contribution of …

Identification of invasion-metastasis-associated microRNAs in hepatocellular carcinoma based on bioinformatic analysis and experimental validation

W Lou, J Chen, B Ding, D Chen, H Zheng… - Journal of translational …, 2018 - Springer
Background Hepatocellular carcinoma (HCC) is one of the most lethal cancer, mainly
attributing to its high tendency to metastasis. Vascular invasion provides a direct path for …

Pathobiology of pulmonary artery hypertension: role of long non-coding RNAs

KR Zahid, U Raza, J Chen, UJ Raj… - Cardiovascular …, 2020 - academic.oup.com
Pulmonary arterial hypertension (PAH) is a disease with complex pathobiology, significant
morbidity and mortality, and remains without a cure. It is characterized by vascular …

LncRNA Tug1 involves in the pulmonary vascular remodeling in mice with hypoxic pulmonary hypertension via the microRNA-374c-mediated Foxc1

L Yang, H Liang, L Shen, Z Guan, X Meng - Life sciences, 2019 - Elsevier
Hypoxic pulmonary hypertension (HPH) is a serious and potentially devastating disorder of
the pulmonary circulation with complicated mechanisms. Long non-coding RNA (lncRNA) …

Long noncoding RNA-maternally expressed gene 3 contributes to hypoxic pulmonary hypertension

Y Xing, X Zheng, Y Fu, J Qi, M Li, M Ma, S Wang, S Li… - Molecular Therapy, 2019 - cell.com
The expression and function of long noncoding RNAs (lncRNAs) in the development of
hypoxic pulmonary hypertension (HPH), especially in the proliferation of pulmonary artery …

MiRNAs, lncRNAs, and circular RNAs as mediators in hypertension-related vascular smooth muscle cell dysfunction

JR Zhang, HJ Sun - Hypertension Research, 2021 - nature.com
Hypertension is a multifactorial disorder that involves complex genetic and environmental
factors. Vascular smooth muscle cells (VSMCs) are important components of blood vessels …