Unraveling the epigenetic landscape of pulmonary arterial hypertension: implications for personalized medicine development
Pulmonary arterial hypertension (PAH) is a multifactorial disease associated with the
remodeling of pulmonary blood vessels. If left unaddressed, PAH can lead to right heart …
remodeling of pulmonary blood vessels. If left unaddressed, PAH can lead to right heart …
Micro-RNA analysis in pulmonary arterial hypertension: current knowledge and challenges
CA Santos-Ferreira, MT Abreu, CI Marques… - Basic to Translational …, 2020 - jacc.org
Pulmonary arterial hypertension (PAH) is a rare, chronic disease of the pulmonary
vasculature that is associated with poor outcomes. Its pathogenesis is multifactorial and …
vasculature that is associated with poor outcomes. Its pathogenesis is multifactorial and …
Mesenchymal stromal cells-derived exosomes alleviate ischemia/reperfusion injury in mouse lung by transporting anti-apoptotic miR-21-5p
J wei Li, L Wei, Z Han, Z Chen - European Journal of Pharmacology, 2019 - Elsevier
Abstract MiR-21-5p is an anti-apoptotic miRNA known to mediate the protective effect of
mesenchymal stromal cell-secreted exosomes (MSC-Exo) against oxidative stress-induced …
mesenchymal stromal cell-secreted exosomes (MSC-Exo) against oxidative stress-induced …
The m6A methyltransferase METTL3 promotes hypoxic pulmonary arterial hypertension
Y Qin, Y Qiao, L Li, E Luo, D Wang, Y Yao, C Tang… - Life sciences, 2021 - Elsevier
Abstract Aims N 6-methyladenosine (m 6 A) is the most prevalent internal chemical RNA
modification in mammal mRNAs. Accumulating evidence has shown the critical role of m 6 A …
modification in mammal mRNAs. Accumulating evidence has shown the critical role of m 6 A …
[HTML][HTML] LncRNA-MTA2TR functions as a promoter in pancreatic cancer via driving deacetylation-dependent accumulation of HIF-1α
Z Zeng, F Xu, H Zheng, P Cheng, Q Chen, Z Ye… - Theranostics, 2019 - ncbi.nlm.nih.gov
Rationale: Hypoxia has been proved to contribute to aggressive phenotype of cancers, while
functional and regulatory mechanism of long noncoding RNA (lncRNA) in the contribution of …
functional and regulatory mechanism of long noncoding RNA (lncRNA) in the contribution of …
Identification of invasion-metastasis-associated microRNAs in hepatocellular carcinoma based on bioinformatic analysis and experimental validation
W Lou, J Chen, B Ding, D Chen, H Zheng… - Journal of translational …, 2018 - Springer
Background Hepatocellular carcinoma (HCC) is one of the most lethal cancer, mainly
attributing to its high tendency to metastasis. Vascular invasion provides a direct path for …
attributing to its high tendency to metastasis. Vascular invasion provides a direct path for …
Pathobiology of pulmonary artery hypertension: role of long non-coding RNAs
Pulmonary arterial hypertension (PAH) is a disease with complex pathobiology, significant
morbidity and mortality, and remains without a cure. It is characterized by vascular …
morbidity and mortality, and remains without a cure. It is characterized by vascular …
LncRNA Tug1 involves in the pulmonary vascular remodeling in mice with hypoxic pulmonary hypertension via the microRNA-374c-mediated Foxc1
L Yang, H Liang, L Shen, Z Guan, X Meng - Life sciences, 2019 - Elsevier
Hypoxic pulmonary hypertension (HPH) is a serious and potentially devastating disorder of
the pulmonary circulation with complicated mechanisms. Long non-coding RNA (lncRNA) …
the pulmonary circulation with complicated mechanisms. Long non-coding RNA (lncRNA) …
Long noncoding RNA-maternally expressed gene 3 contributes to hypoxic pulmonary hypertension
Y Xing, X Zheng, Y Fu, J Qi, M Li, M Ma, S Wang, S Li… - Molecular Therapy, 2019 - cell.com
The expression and function of long noncoding RNAs (lncRNAs) in the development of
hypoxic pulmonary hypertension (HPH), especially in the proliferation of pulmonary artery …
hypoxic pulmonary hypertension (HPH), especially in the proliferation of pulmonary artery …
MiRNAs, lncRNAs, and circular RNAs as mediators in hypertension-related vascular smooth muscle cell dysfunction
JR Zhang, HJ Sun - Hypertension Research, 2021 - nature.com
Hypertension is a multifactorial disorder that involves complex genetic and environmental
factors. Vascular smooth muscle cells (VSMCs) are important components of blood vessels …
factors. Vascular smooth muscle cells (VSMCs) are important components of blood vessels …