Understanding COVID-19-associated coagulopathy

EM Conway, N Mackman, RQ Warren… - Nature Reviews …, 2022 - nature.com
Abstract COVID-19-associated coagulopathy (CAC) is a life-threatening complication of
SARS-CoV-2 infection. However, the underlying cellular and molecular mechanisms driving …

Airborne transmission of respiratory viruses

CC Wang, KA Prather, J Sznitman, JL Jimenez… - Science, 2021 - science.org
BACKGROUND Exposure to droplets produced in the coughs and sneezes of infected
individuals or contact with droplet-contaminated surfaces (fomites) have been widely …

[HTML][HTML] Infectious viral load in unvaccinated and vaccinated individuals infected with ancestral, Delta or Omicron SARS-CoV-2

O Puhach, K Adea, N Hulo, P Sattonnet, C Genecand… - Nature medicine, 2022 - nature.com
Infectious viral load (VL) expelled as droplets and aerosols by infected individuals partly
determines transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

[HTML][HTML] Safety, tolerability and viral kinetics during SARS-CoV-2 human challenge in young adults

B Killingley, AJ Mann, M Kalinova, A Boyers… - Nature Medicine, 2022 - nature.com
Since its emergence in 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) has caused hundreds of millions of cases and continues to circulate globally. To establish …

SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters

PJ Halfmann, S Iida, K Iwatsuki-Horimoto, T Maemura… - Nature, 2022 - nature.com
The recent emergence of B. 1.1. 529, the Omicron variant,, has raised concerns of escape
from protection by vaccines and therapeutic antibodies. A key test for potential …

SARS-CoV-2 infection in free-ranging white-tailed deer

VL Hale, PM Dennis, DS McBride, JM Nolting… - Nature, 2022 - nature.com
Humans have infected a wide range of animals with SARS-CoV-2,,,–, but the establishment
of a new natural animal reservoir has not been observed. Here we document that free …

COVID-19 vaccine development: milestones, lessons and prospects

M Li, H Wang, L Tian, Z Pang, Q Yang… - Signal transduction and …, 2022 - nature.com
With the constantly mutating of SARS-CoV-2 and the emergence of Variants of Concern
(VOC), the implementation of vaccination is critically important. Existing SARS-CoV-2 …

Characterization and antiviral susceptibility of SARS-CoV-2 Omicron BA. 2

R Uraki, M Kiso, S Iida, M Imai, E Takashita, M Kuroda… - Nature, 2022 - nature.com
The recent emergence of SARS-CoV-2 Omicron (B. 1.1. 529 lineage) variants possessing
numerous mutations has raised concerns of decreased effectiveness of current vaccines …

Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine

Z Wang, KD Popowski, D Zhu… - Nature biomedical …, 2022 - nature.com
The first two mRNA vaccines against infection by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) that were approved by regulators require a cold chain and …

The state of complement in COVID-19

B Afzali, M Noris, BN Lambrecht… - Nature Reviews …, 2022 - nature.com
Hyperactivation of the complement and coagulation systems is recognized as part of the
clinical syndrome of COVID-19. Here we review systemic complement activation and local …