[HTML][HTML] Biomedical application of aggregation-induced emission luminogen-based fluorescent sensors

Y Duo, Z Xiang, G Gao, G Luo, BZ Tang - TrAC Trends in Analytical …, 2023 - Elsevier
Fluorescent biosensors are powerful analytical tools that have been widely employed in a
range of in vitro and in vivo biomedical applications. However, traditional fluorophores …

Application of silicon nanowire field effect transistor (SiNW-FET) biosensor with high sensitivity

H Li, D Li, H Chen, X Yue, K Fan, L Dong, G Wang - Sensors, 2023 - mdpi.com
As a new type of one-dimensional semiconductor nanometer material, silicon nanowires
(SiNWs) possess good application prospects in the field of biomedical sensing. SiNWs have …

Protein aggregation and neurodegenerative disease: structural outlook for the novel therapeutics

S Arar, MA Haque, R Kayed - Proteins: Structure, Function, and …, 2023 - Wiley Online Library
Before the controversial approval of humanized monoclonal antibody lecanemab, which
binds to the soluble amyloid‐β protofibrils, all the treatments available earlier, for …

Chitosan functionalized gold nanostars as a theranostic platform for intracellular microRNA detection and photothermal therapy

X Dong, Z Zhu, Q Sun, H Zhang, C Yang - Journal of Materials …, 2023 - pubs.rsc.org
The development of a theranostic platform that integrates both diagnostic and therapeutic
capabilities is in great need for precise and personalized medicine. Here, we present a …

High AIECL performance of tetraphenylethene derivatives originated from the linear increasing of benzene ring and solvent regulation for sensitive measurement of …

Z Wang, W Cao, R Yuan, H Wang - Biosensors and Bioelectronics, 2023 - Elsevier
The efficiency of aggregation-induced electrochemiluminescence (AIECL) in
tetraphenylethene (TPE) derivatives were significantly enhanced by combining the …

Vertical graphene-based printed electrochemical biosensor for simultaneous detection of four Alzheimer's disease blood biomarkers

M Li, Y Zeng, Z Huang, L Zhang, Y Liu - Biosensors, 2023 - mdpi.com
Early detection and timely intervention play a vital role in the effective management of
Alzheimer's disease. Currently, the diagnostic accuracy for Alzheimer's disease based on a …

Ratiometric fluorescence sensing NADH using AIE-dots transducers at the point of care

S Deng, X Men, M Hu, X Liang, Y Dai, Z Zhan… - Biosensors and …, 2024 - Elsevier
Reduced nicotinamide adenine dinucleotide (NADH) has a strong impact on physiological
metabolism, and its concentration is related to metabolic and neurodegenerative diseases …

A MoS2 nanosheet-based CRISPR/Cas12a biosensor for efficient miRNA quantification for acute myocardial infarction

P Li, Y Ye, Y Li, Z Xie, L Ye, J Huang - Biosensors and Bioelectronics, 2024 - Elsevier
Acute myocardial infarction (AMI) represents the leading cause of cardiovascular death
worldwide, and it is thus pivotal to develop effective approaches for the timely detection of …

β-Galactosidase-activated near-infrared AIEgen for ovarian cancer imaging in vivo

L Xu, H Gao, Y Deng, X Liu, W Zhan, X Sun… - Biosensors and …, 2024 - Elsevier
Near-infrared (NIR) aggregation induced-emission luminogens (AIEgens) circumvent the
noisome aggregation-caused quenching (ACQ) effect in physiological milieu, thus holding …

An Aggregation-Induced Emission-Based Dual Emitting Nanoprobe for Detecting Intracellular pH and Unravelling Metabolic Variations in Differentiating Lymphocytes

Y Huang, Q Zhang, CYK Lam, C Li, C Yang, Z Zhong… - ACS …, 2024 - ACS Publications
Monitoring T lymphocyte differentiation is essential for understanding T cell fate regulation
and advancing adoptive T cell immunotherapy. However, current biomarker analysis …