The emergence of drug-resistant fungi poses a major threat to human health. Despite
advances in preventive, diagnostic, and therapeutic interventions, resistant fungal infections …

The alarming rise in antibiotic-resistant pathogens has coincided with a decline in the supply
of new antibiotics. It is therefore of great importance to find and create new antibiotics …

Carbohydrates serve many structural and functional roles in biology. While the majority of
monosaccharides are characterized by the chemical composition (CH2O) n, modifications …

Candida albicans-mediated vulvovaginal candidiasis (VVC) is a significant challenge in
clinical settings, owing to the inefficacy of current antifungals in modulating virulence …

Kinases are annotated in many nucleoside biosynthetic gene clusters but generally are
considered responsible only for self-resistance. Here, we report an unexpected 2 …

Exploring a new target for antibacterial drug discovery has gained much attention because
of the emergence of Multidrug Resistance (MDR) strains of bacteria. To overcome this …

Nikkomycins and polyoxins are antifungal peptidylnucleoside antibiotics active against
human and plant pathogens. Here we report that during peptidylnucleoside biosynthesis in …

Methyluridine (5-MU) is a prominent intermediate for industrial synthesis of several antiviral-
drugs, however, its availability over the past decades has overwhelmingly relied on …

Covering: up to September 2020 Hundreds of nucleoside-based natural products have been
isolated from various microorganisms, several of which have been utilized in agriculture as …

Glycoconjugates are the most diverse biomolecules of life. Mostly located at the cell surface,
they translate into cell-specific “barcodes” and offer a vast repertoire of functions, including …