The formation of amyloid fibers is associated with a diverse range of disease and phenotypic
states. These amyloid fibers often assemble into multi-protofibril, high-order architectures in …

Sup35p is an essential protein in yeast that functions in complex with Sup45p for efficient
translation termination. Although some may argue that this function is the only important …

Transmissible spongiform encephalopathies (TSEs) or prion diseases are fatal
neurodegenerative diseases with no approved therapeutics. TSE pathology is characterized …

Prions are conformationally flexible proteins capable of adopting a native state and a
spectrum of alternative states associated with a change in the function of the protein. These …

Prions are proteins capable of adopting misfolded conformations and transmitting these
conformations to other normally folded proteins. Prions are most commonly known for …

The yeast [PSI+] prion originates from the self‐perpetuating transmissible aggregates of the
translation termination factor Sup35p. We previously showed that infectious Sup35p …

Prion diseases are a family of fatal proteinopathies that are associated with progressive
neurodegeneration, such as Creutzfeldt–Jakob disease, bovine spongiform encephalitis …

Liquid-liquid phase separation (LLPS) and liquid-solid phase transition (LSPT) of
amyloidogenic proteins are now being intensively studied as a potentially widespread …

Chaperone networks are required for the shearing and generation of transmissible
propagons from pre‐existing prion aggregates. However, other cellular networks needed for …

Epigenetic mechanisms of inheritance have come to occupy a prominent place in our
understanding of living systems, primarily eukaryotes. There has been considerable and …