Natural compounds as inhibitors of Aβ peptide aggregation: chemical requirements and molecular mechanisms

K Pagano, S Tomaselli, H Molinari… - Frontiers in …, 2020 - frontiersin.org
Alzheimer's disease (AD) is one of the most common neurodegenerative disorders, with no
cure and preventive therapy. Misfolding and extracellular aggregation of Amyloid-β (Aβ) …

Green tea epigallocatechin-3-gallate (EGCG) targeting protein misfolding in drug discovery for neurodegenerative diseases

PB Gonçalves, ACR Sodero, Y Cordeiro - Biomolecules, 2021 - mdpi.com
The potential to treat neurodegenerative diseases (NDs) of the major bioactive compound of
green tea, epigallocatechin-3-gallate (EGCG), is well documented. Numerous findings now …

Applications of nuclear magnetic resonance spectroscopy to the evaluation of complex food constituents

R Cao, X Liu, Y Liu, X Zhai, T Cao, A Wang, J Qiu - Food chemistry, 2021 - Elsevier
Due to a number of unparalleled advantages such as fastness, accuracy, intactness, nuclear
magnetic resonance spectroscopy (NMR) has fulfilled a significant role in determining …

Tea category identification using a novel fractional Fourier entropy and Jaya algorithm

Y Zhang, X Yang, C Cattani, RV Rao, S Wang… - Entropy, 2016 - mdpi.com
This work proposes a tea-category identification (TCI) system, which can automatically
determine tea category from images captured by a 3 charge-coupled device (CCD) digital …

Identification of green, oolong and black teas in China via wavelet packet entropy and fuzzy support vector machine

S Wang, X Yang, Y Zhang, P Phillips, J Yang, TF Yuan - Entropy, 2015 - mdpi.com
To develop an automatic tea-category identification system with a high recall rate, we
proposed a computer-vision and machine-learning based system, which did not require …

Molecular mechanism for the (−)-epigallocatechin gallate-induced toxic to nontoxic remodeling of Aβ oligomers

R Ahmed, B VanSchouwen, N Jafari, X Ni… - Journal of the …, 2017 - ACS Publications
(−)-Epigallocatechin gallate (EGCG) effectively reduces the cytotoxicity of the Alzheimer's
disease β-amyloid peptide (Aβ) by remodeling seeding-competent Aβ oligomers into off …

Green tea polyphenol epigallocatechin-gallate in amyloid aggregation and neurodegenerative diseases

L Fernandes, TR Cardim-Pires, D Foguel… - Frontiers in …, 2021 - frontiersin.org
The accumulation of protein aggregates in human tissues is a hallmark of more than 40
diseases called amyloidoses. In seven of these disorders, the aggregation is associated with …

Atomic resolution map of the soluble amyloid beta assembly toxic surfaces

R Ahmed, M Akcan, A Khondker, MC Rheinstädter… - Chemical …, 2019 - pubs.rsc.org
Soluble amyloid beta assemblies (Aβn) are neurotoxic and play a central role in the early
phases of the pathogenesis cascade leading to Alzheimer's disease. However, the current …

Roles of Apigenin and Nepetin in the assembly behavior and cytotoxicity of prion neuropeptide PrP106-126

Y Huo, C Zhao, Y Wang, S Wang, T Mu… - ACS Chemical …, 2023 - ACS Publications
Development of potential inhibitors to prevent prion protein (PrP) fibrillation is a therapeutic
strategy for prion diseases. The prion neuropeptide PrP106-126, a research model of …

Flavonoids in the treatment of Alzheimer's and other neurodegenerative diseases

C Airoldi, B La Ferla, G D'Orazio… - Current medicinal …, 2018 - ingentaconnect.com
Flavonoids are phytochemicals present in almost all terrestrial plants and, as a
consequence, in plant-based foods, and thus consumed by humans through diet. Recent …