Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine
Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …
now can generate most cells of the human body in the laboratory. PSC-derived …
Cardiomyocyte maturation: new phase in development
Y Guo, WT Pu - Circulation research, 2020 - Am Heart Assoc
Maturation is the last phase of heart development that prepares the organ for strong,
efficient, and persistent pumping throughout the mammal's lifespan. This process is …
efficient, and persistent pumping throughout the mammal's lifespan. This process is …
Human-iPSC-derived cardiac stromal cells enhance maturation in 3D cardiac microtissues and reveal non-cardiomyocyte contributions to heart disease
Cardiomyocytes (CMs) from human induced pluripotent stem cells (hiPSCs) are functionally
immature, but this is improved by incorporation into engineered tissues or forced contraction …
immature, but this is improved by incorporation into engineered tissues or forced contraction …
In situ expansion, differentiation, and electromechanical coupling of human cardiac muscle in a 3D bioprinted, chambered organoid
Rationale: One goal of cardiac tissue engineering is the generation of a living, human pump
in vitro that could replace animal models and eventually serve as an in vivo therapeutic …
in vitro that could replace animal models and eventually serve as an in vivo therapeutic …
Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest
The mammalian heart undergoes maturation during postnatal life to meet the increased
functional requirements of an adult. However, the key drivers of this process remain poorly …
functional requirements of an adult. However, the key drivers of this process remain poorly …
Metabolically driven maturation of human-induced-pluripotent-stem-cell-derived cardiac microtissues on microfluidic chips
The immature physiology of cardiomyocytes derived from human induced pluripotent stem
cells (hiPSCs) limits their utility for drug screening and disease modelling. Here we show …
cells (hiPSCs) limits their utility for drug screening and disease modelling. Here we show …
Single-cell resolution of temporal gene expression during heart development
DM DeLaughter, AG Bick, H Wakimoto, D McKean… - Developmental cell, 2016 - cell.com
Activation of complex molecular programs in specific cell lineages governs mammalian
heart development, from a primordial linear tube to a four-chamber organ. To characterize …
heart development, from a primordial linear tube to a four-chamber organ. To characterize …
Drug screening in human PSC-cardiac organoids identifies pro-proliferative compounds acting via the mevalonate pathway
We have previously developed a high-throughput bioengineered human cardiac organoid
(hCO) platform, which provides functional contractile tissue with biological properties similar …
(hCO) platform, which provides functional contractile tissue with biological properties similar …
Stem cell therapy in heart diseases–cell types, mechanisms and improvement strategies
P Müller, H Lemcke, R David - Cellular Physiology and Biochemistry, 2018 - karger.com
A large number of clinical trials have shown stem cell therapy to be a promising therapeutic
approach for the treatment of cardiovascular diseases. Since the first transplantation into …
approach for the treatment of cardiovascular diseases. Since the first transplantation into …
Single-cell transcriptomic analysis of cardiac differentiation from human PSCs reveals HOPX-dependent cardiomyocyte maturation
Cardiac differentiation of human pluripotent stem cells (hPSCs) requires orchestration of
dynamic gene regulatory networks during stepwise fate transitions but often generates …
dynamic gene regulatory networks during stepwise fate transitions but often generates …