Heat shock 70 kDa proteins (HSP70s) are ubiquitous molecular chaperones that function in
a myriad of biological processes, modulating polypeptide folding, degradation and …

The retromer complex is a vital element of the endosomal protein sorting machinery that is
conserved across all eukaryotes. Retromer is most closely associated with the endosome-to …

The majority of extracellular vesicle (EV) studies conducted to date have been performed on
cell lines with little knowledge on how well these represent the characteristics of EVs in vivo …

A Saskatchewan multi-incident family was clinically characterized with Parkinson disease
(PD) and Lewy body pathology. PD segregates as an autosomal-dominant trait, which could …

The current mainstay treatment of Parkinson's disease (PD) consists of dopamine
replacement therapy which, in addition to causing several side effects, does not delay …

The evolutionarily conserved endosomal retromer complex rescues transmembrane
proteins from the lysosomal degradative pathway and facilitates their recycling to other …

Heat shock cognate protein 70 (HSC70) is a constitutively expressed molecular chaperone
which belongs to the heat shock protein 70 (HSP70) family. HSC70 shares some of the …

Emerging evidence indicates that heat shock proteins (HSPs) are critical regulators in
normal neural physiological function as well as in cell stress responses. The functions of …

Retromer is a protein assembly that plays a central role in orchestrating export of
transmembrane-spanning cargo proteins from endosomes into retrieval pathways destined …

Neurodegenerative diseases are amongst the most devastating of human disorders. New
technologies have led to a rapid increase in the identification of disease-related genes with …