A hyperinflammatory response to severe acute respiratory syndrome‐coronavirus 2 (SARS‐
CoV‐2) infection, reminiscent of cytokine release syndrome, has been implicated in the …

Proinflammatory cytokine activation of the Janus kinase/signal transducers and activators of
transcription (JAK/STAT) signal transduction pathway is a critical event in the pathogenesis …

Insufficient apoptosis of inflammatory macrophages and osteoclasts (OCs) in rheumatoid
arthritis (RA) joints contributes toward the persistent progression of joint inflammation and …

Chronic kidney disease (CKD) represents a leading cause of death in the United States.
There is no cure for this disease, with current treatment strategies relying on blood pressure …

Objective To evaluate the efficacy, safety and dose response of a novel oral Janus kinase
inhibitor, peficitinib (ASP015K), as monotherapy in Japanese patients with moderate to …

Chronic pain is nowadays considered not only the mainstay symptom of rheumatic diseases
but also “a disease itself.” Pain is a multidimensional phenomenon, and in inflammatory …

Current treatment strategies for inflammatory bowel diseases (IBDs) are associated with a
lower efficacy and with several side effects that strongly affect the quality of life of IBD …

Abstract Inhibition of Janus kinases [JAKs] in Crohn's disease [CD] patients has shown
conflicting results in clinical trials. Tofacitinib, a pan-JAK inhibitor, showed efficacy in …

Nanomaterials have received increasing attention due to their unique chemical and physical
properties for the treatment of rheumatoid arthritis (RA), the most common complex …

Chronic kidney disease (CKD) is a lethal and rapidly increasing burden on society. Despite
this, there are relatively few therapies in development for the treatment of CKD. Several …