Breast cancer (BC) displays striking clinical, morphological, and behavioural diversity within
a single tumour and between tumours. Currently, mounting evidence indicates that the …

Ductal carcinoma in situ (DCIS) is the most frequently diagnosed early‐stage breast cancer.
Only a subset of patients progress to invasive ductal carcinoma (IDC), and this presents a …

Ductal carcinoma in situ (DCIS) is an early-stage breast cancer that infrequently progresses
to invasive ductal carcinoma (IDC). Genomic evolution has been difficult to delineate during …

Breast cancer metastasis remains a clinical challenge, even within a single patient across
multiple sites of the disease. Genome-wide comparisons of both the DNA and gene …

Next generation sequencing is extensively applied to catalogue somatic mutations in
cancer, in research settings and increasingly in clinical settings for molecular diagnostics …

Background High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of
ovarian carcinoma, associated with poor clinical outcome and metastatic disease. Although …

Figure 1 Insertions of Cas9 and gRNA plasmid-derived DNA sequences at the genomic
target site in transiently transfected Arabidopsis protoplasts.(a) T7 endonuclease I (T7EI) …

Although the repertoire of somatic genetic alterations of primary breast cancers has been
extensively catalogued, the genetic differences between primary and metastatic tumors have …

To the Editor: Systematic genomic studies, including the Cancer Genome Atlas (TCGA) 1
and the International Cancer Genome Consortium (ICGC) 2, have provided an …

The drivers of ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) transition
are poorly understood. Here, we conducted an integrated genomic, transcriptomic, and …