Telomeres and telomerase: three decades of progress

JW Shay, WE Wright - Nature Reviews Genetics, 2019 - nature.com
Many recent advances have emerged in the telomere and telomerase fields. This Timeline
article highlights the key advances that have expanded our views on the mechanistic …

Alveolar epithelial type II cells as drivers of lung fibrosis in idiopathic pulmonary fibrosis

T Parimon, C Yao, BR Stripp, PW Noble… - International journal of …, 2020 - mdpi.com
Alveolar epithelial type II cells (AT2) are a heterogeneous population that have critical
secretory and regenerative roles in the alveolus to maintain lung homeostasis. However …

Macrophages: friend or foe in idiopathic pulmonary fibrosis?

L Zhang, Y Wang, G Wu, W Xiong, W Gu, CY Wang - Respiratory research, 2018 - Springer
Idiopathic pulmonary fibrosis (IPF) is a prototype of lethal, chronic, progressive interstitial
lung disease of unknown etiology. Over the past decade, macrophage has been recognized …

Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease

AL Mora, M Rojas, A Pardo, M Selman - Nature reviews Drug discovery, 2017 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a fatal age-associated disease that is characterized by
progressive and irreversible scarring of the lung. The pathogenesis of IPF is not completely …

Idiopathic pulmonary fibrosis (IPF): an overview

SL Barratt, A Creamer, C Hayton… - Journal of clinical …, 2018 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterised by chronic,
progressive scarring of the lungs and the pathological hallmark of usual interstitial …

Telomere-mediated lung disease

JK Alder, M Armanios - Physiological reviews, 2022 - journals.physiology.org
Parenchymal lung disease is the fourth leading cause of death in the United States; among
the top causes, it continues on the rise. Telomeres and telomerase have historically been …

Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening

BD Stuart, J Choi, S Zaidi, C Xing, B Holohan, R Chen… - Nature …, 2015 - nature.com
Idiopathic pulmonary fibrosis (IPF) is an age-related disease featuring progressive lung
scarring. To elucidate the molecular basis of IPF, we performed exome sequencing of …

The telomere syndromes

M Armanios, EH Blackburn - Nature Reviews Genetics, 2012 - nature.com
There has been mounting evidence of a causal role for telomere dysfunction in a number of
degenerative disorders. Their manifestations encompass common disease states such as …

Idiopathic pulmonary fibrosis beyond the lung: understanding disease mechanisms to improve diagnosis and management

F Luppi, M Kalluri, P Faverio, M Kreuter, G Ferrara - Respiratory Research, 2021 - Springer
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive disorder with an estimated
median survival time of 3–5 years after diagnosis. This condition occurs primarily in elderly …

Treatment of fibrotic interstitial lung disease: current approaches and future directions

KA Johannson, N Chaudhuri, A Adegunsoye… - The Lancet, 2021 - thelancet.com
Fibrotic interstitial lung disease (ILD) represents a large group of pulmonary disorders that
are often progressive and associated with high morbidity and early mortality. Important …