Telomeres and telomerase: three decades of progress
JW Shay, WE Wright - Nature Reviews Genetics, 2019 - nature.com
Many recent advances have emerged in the telomere and telomerase fields. This Timeline
article highlights the key advances that have expanded our views on the mechanistic …
article highlights the key advances that have expanded our views on the mechanistic …
Alveolar epithelial type II cells as drivers of lung fibrosis in idiopathic pulmonary fibrosis
Alveolar epithelial type II cells (AT2) are a heterogeneous population that have critical
secretory and regenerative roles in the alveolus to maintain lung homeostasis. However …
secretory and regenerative roles in the alveolus to maintain lung homeostasis. However …
Macrophages: friend or foe in idiopathic pulmonary fibrosis?
L Zhang, Y Wang, G Wu, W Xiong, W Gu, CY Wang - Respiratory research, 2018 - Springer
Idiopathic pulmonary fibrosis (IPF) is a prototype of lethal, chronic, progressive interstitial
lung disease of unknown etiology. Over the past decade, macrophage has been recognized …
lung disease of unknown etiology. Over the past decade, macrophage has been recognized …
Emerging therapies for idiopathic pulmonary fibrosis, a progressive age-related disease
Idiopathic pulmonary fibrosis (IPF) is a fatal age-associated disease that is characterized by
progressive and irreversible scarring of the lung. The pathogenesis of IPF is not completely …
progressive and irreversible scarring of the lung. The pathogenesis of IPF is not completely …
Idiopathic pulmonary fibrosis (IPF): an overview
SL Barratt, A Creamer, C Hayton… - Journal of clinical …, 2018 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterised by chronic,
progressive scarring of the lungs and the pathological hallmark of usual interstitial …
progressive scarring of the lungs and the pathological hallmark of usual interstitial …
Telomere-mediated lung disease
JK Alder, M Armanios - Physiological reviews, 2022 - journals.physiology.org
Parenchymal lung disease is the fourth leading cause of death in the United States; among
the top causes, it continues on the rise. Telomeres and telomerase have historically been …
the top causes, it continues on the rise. Telomeres and telomerase have historically been …
Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening
Idiopathic pulmonary fibrosis (IPF) is an age-related disease featuring progressive lung
scarring. To elucidate the molecular basis of IPF, we performed exome sequencing of …
scarring. To elucidate the molecular basis of IPF, we performed exome sequencing of …
The telomere syndromes
M Armanios, EH Blackburn - Nature Reviews Genetics, 2012 - nature.com
There has been mounting evidence of a causal role for telomere dysfunction in a number of
degenerative disorders. Their manifestations encompass common disease states such as …
degenerative disorders. Their manifestations encompass common disease states such as …
Idiopathic pulmonary fibrosis beyond the lung: understanding disease mechanisms to improve diagnosis and management
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive disorder with an estimated
median survival time of 3–5 years after diagnosis. This condition occurs primarily in elderly …
median survival time of 3–5 years after diagnosis. This condition occurs primarily in elderly …
Treatment of fibrotic interstitial lung disease: current approaches and future directions
Fibrotic interstitial lung disease (ILD) represents a large group of pulmonary disorders that
are often progressive and associated with high morbidity and early mortality. Important …
are often progressive and associated with high morbidity and early mortality. Important …