Aging is characterized by a progressive impairment of (a) cardiac structure including fibrosis
and cardiomyocyte density, and (b) cardiac function including stroke volume, ejection …

The process of restenosis is based on the interplay of various mechanical and biological
processes triggered by angioplasty-induced vascular trauma. Early arterial recoil, negative …

Despite significant advances in the understanding of tissue responses to biomaterials, most
implants are still plagued by inflammatory responses which can lead to fibrotic …

Successful tissue engineering requires optimization of scaffold stiffness for a given
application and cell type. Here, we investigated the effect of scaffold stiffness on myoblast …

Bone marrow-derived mesenchymal stem cells (BMSCs) are relatively accessible and
exhibit a pluripotency suitable for cardiovascular applications such as tissue-engineered …

Emodin (1, 3, 8-trihydroxy-6-methyl-anthraquinone) is an anthraquinone derivative from the
roots of Rheum officinale Baill, a Chinese herb widely and traditionally used for wound …

There is a clinical need for a functional tissue-engineered blood vessel because small-
caliber arterial graft (< 5 mm) applications are limited by the availability of suitable …

Integrins are cell adhesion receptors predominantly important during normal and tumor
angiogenesis. A sequence present on several extracellular matrix proteins composed of Arg …

The extracellular matrix (ECM) is a network of structural proteins, glycoproteins and
proteoglycans that assists independent cells in aggregating and forming highly organized …

Human pluripotent stem cells (hPSCs) possess great value for biomedical research. hPSCs
can be scaled and differentiated to all cell types found in the human body. The differentiation …