Pore-forming toxins (PFTs) are the most common bacterial cytotoxic proteins and are
required for virulence in a large number of important pathogens, including Streptococcus …

Staphylococcus aureus is a prominent human pathogen capable of infecting a variety of host
species and tissue sites. This versatility stems from the pathogen's ability to secrete diverse …

The precise assembly and engineering of molecular machines capable of handling
biomolecules play crucial roles in most single-molecule methods. In this work we use …

For many of the most important human bacterial infections, invasive disease severity is
fueled by the cell damaging and pro-inflammatory effects of secreted pore-forming toxins …

To intoxicate cells, pore-forming bacterial toxins are evolved to allow for the transmembrane
traffic of different substrates, ranging from small inorganic ions to cell-specific polypeptides …

Epsilon toxin (ET), produced by Clostridium perfringens types B and D, ranks among the four
most potent poisonous substances known so far. ET-intoxication is responsible for …

Protective antigen channel is the central component of the deadly anthrax exotoxin
responsible for binding and delivery of the toxin's enzymatic lethal and edema factor …

Introduction: Present-day rational drug design approaches are based on exploiting unique
features of the target biomolecules, small-or macromolecule drug candidates and physical …

The focus of this review is on the biophysical studies of the channel-forming bacterial toxins
that shed light upon the mechanisms of their toxicity and propose new approaches to block …

In an effort to identify the optimal cyclodextrin (CD) host for delivery of penicillins to
mammalian cells that will also offer protection against β-lactamase-induced hydrolysis …