In bacteria, many essential metabolic processes are controlled by riboswitches, gene
regulatory RNAs that directly bind and detect metabolites. Highly specific effector binding …

Abstract “Fairy rings” resulting from fungus-stimulated plant growth occur all over the world.
In 2010, 2-azahypoxanthine (AHX) from a fungus Lepista sordida was identified as the “fairy” …

Cobamides are cobalt-containing cyclic tetrapyrroles used by cells from all domains of life
but only produced de novo by some bacteria and archaea. The “late steps” of the …

Cobamides, which include vitamin B12 (cobalamin), are a class of modified tetrapyrroles
synthesized exclusively by prokaryotes that function as cofactors for diverse biological …

Vitamin B12 or cobalamin is an essential metabolite for humans, which makes it an
interesting compound for many research groups that focus in different producer-strains …

Cobamides are coenzymes used by cells from all domains of life but made de novo by only
some bacteria and archaea. The last steps of the cobamide biosynthetic pathway activate …

Cobamides (Cbas) are coenzymes used by cells across all domains of life, but de novo
synthesis is only found in some bacteria and archaea. Five enzymes assemble the …

Salmonella enterica subsp. enterica sv. Typhimurium str. LT2 (hereafter S. Typhimurium)
synthesizes adenosylcobalamin (AdoCbl, CoB 12) de novo only under anoxic conditions …

Dimethylbenzimidazolyl‐(DMB)‐α‐ribotide [α‐ribazole‐5′‐phosphate (α‐RP)] is an
intermediate in the biosynthesis of adenosylcobalamin (AdoCbl) in many prokaryotes. In …

Vitamin B 12 and other cobamides are essential cofactors required by many organisms and
are synthesized by a subset of prokaryotes via distinct aerobic and anaerobic routes. The …