Ecology and evolution of Mycobacterium tuberculosis

S Gagneux - Nature Reviews Microbiology, 2018 - nature.com
Tuberculosis (TB) is the number one cause of human death due to an infectious disease.
The causative agents of TB are a group of closely related bacteria known as the …

Co‐evolution of Mycobacterium tuberculosis and Homo sapiens

D Brites, S Gagneux - Immunological reviews, 2015 - Wiley Online Library
The causative agent of human tuberculosis (TB), M ycobacterium tuberculosis, is an obligate
pathogen that evolved to exclusively persist in human populations. For M. tuberculosis to …

Host–pathogen coevolution in human tuberculosis

S Gagneux - … Transactions of the Royal Society B …, 2012 - royalsocietypublishing.org
Tuberculosis (TB) is a disease of antiquity. Yet TB today still causes more adult deaths than
any other single infectious disease. Recent studies show that contrary to the common view …

Mycobacterium smegmatis: the vanguard of mycobacterial research

IL Sparks, KM Derbyshire, WR Jacobs Jr… - Journal of …, 2023 - Am Soc Microbiol
The genus Mycobacterium contains several slow-growing human pathogens, including
Mycobacterium tuberculosis, Mycobacterium leprae, and Mycobacterium avium …

A New Phylogenetic Framework for the Animal-Adapted Mycobacterium tuberculosis Complex

D Brites, C Loiseau, F Menardo, S Borrell… - Frontiers in …, 2018 - frontiersin.org
Tuberculosis (TB) affects humans and other animals and is caused by bacteria from the
Mycobacterium tuberculosis complex (MTBC). Previous studies have shown that there are at …

Global phylogeography of Mycobacterium tuberculosis and implications for tuberculosis product development

S Gagneux, PM Small - The Lancet infectious diseases, 2007 - thelancet.com
New tools for controlling tuberculosis are urgently needed. Despite our emerging
understanding of the biogeography of Mycobacterium tuberculosis, the implications for …

High functional diversity in Mycobacterium tuberculosis driven by genetic drift and human demography

R Hershberg, M Lipatov, PM Small, H Sheffer… - PLoS …, 2008 - journals.plos.org
Mycobacterium tuberculosis infects one third of the human world population and kills
someone every 15 seconds. For more than a century, scientists and clinicians have been …

Microbial diversity and the genetic nature of microbial species

M Achtman, M Wagner - Nature reviews microbiology, 2008 - nature.com
The earth contains a huge number of largely uncharacterized Bacteria and Archaea.
Microbiologists are struggling to summarize their genetic diversity and classify them, which …

Mycobacterium bovis at the animal–human interface: A problem, or not?

AL Michel, B Müller, PD Van Helden - Veterinary microbiology, 2010 - Elsevier
Mycobacterium bovis is a pathogen of significant importance in livestock and a wide range
of wild animal species worldwide. It is also known to cause tuberculosis disease in humans …

Evolution, population structure, and phylogeography of genetically monomorphic bacterial pathogens

M Achtman - Annu. Rev. Microbiol., 2008 - annualreviews.org
Genetically monomorphic bacteria contain so little sequence diversity that sequencing a few
gene fragments yields little or no information. As a result, our understanding of their …