A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human
genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion …

Axons are generally considered as reliable transmission cables in which stable propagation
occurs once an action potential is generated. Axon dysfunction occupies a central position in …

At a synapse, fast synchronous neurotransmitter release requires localization of Ca 2+
channels to presynaptic active zones. How Ca 2+ channels are recruited to active zones …

Calcium regulates a wide spectrum of physiological processes such as heartbeat, muscle
contraction, neuronal communication, hormone release, cell division, and gene …

Synapses are specialized intercellular junctions in which cell adhesion molecules connect
the presynaptic machinery for neurotransmitter release to the postsynaptic machinery for …

Recent research has identified some key players involved in the proteolytic processing of
amyloid precursor protein (APP) to amyloid β-peptide, the principal component of the …

▪ Abstract The intrinsic electrical properties of neurons are shaped in large part by the action
of voltage-gated ion channels. Molecular cloning studies have revealed a large family of ion …

Local Ca2+ signaling occurring within nanometers of voltage-gated Ca2+ (Cav) channels is
crucial for CNS function, yet the molecular composition of Cav channel nano-environments …

▪ Abstract Tissue development, differentiation, and physiology require specialized cellular
adhesion and signal transduction at sites of cell-cell contact. Scaffolding proteins that tether …

The active zone is a specialized region of the presynaptic plasma membrane where synaptic
vesicles dock and fuse. In this study, we have investigated the cellular mechanism …