The sequence of the human genome
A 2.91-billion base pair (bp) consensus sequence of the euchromatic portion of the human
genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion …
genome was generated by the whole-genome shotgun sequencing method. The 14.8-billion …
Axon physiology
D Debanne, E Campanac, A Bialowas… - Physiological …, 2011 - journals.physiology.org
Axons are generally considered as reliable transmission cables in which stable propagation
occurs once an action potential is generated. Axon dysfunction occupies a central position in …
occurs once an action potential is generated. Axon dysfunction occupies a central position in …
[HTML][HTML] RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction
At a synapse, fast synchronous neurotransmitter release requires localization of Ca 2+
channels to presynaptic active zones. How Ca 2+ channels are recruited to active zones …
channels to presynaptic active zones. How Ca 2+ channels are recruited to active zones …
The β Subunit of Voltage-Gated Ca2+ Channels
Calcium regulates a wide spectrum of physiological processes such as heartbeat, muscle
contraction, neuronal communication, hormone release, cell division, and gene …
contraction, neuronal communication, hormone release, cell division, and gene …
α-Neurexins couple Ca2+ channels to synaptic vesicle exocytosis
M Missler, W Zhang, A Rohlmann, G Kattenstroth… - Nature, 2003 - nature.com
Synapses are specialized intercellular junctions in which cell adhesion molecules connect
the presynaptic machinery for neurotransmitter release to the postsynaptic machinery for …
the presynaptic machinery for neurotransmitter release to the postsynaptic machinery for …
Proteolytic processing and cell biological functions of the amyloid precursor protein
B De Strooper, W Annaert - Journal of cell science, 2000 - journals.biologists.com
Recent research has identified some key players involved in the proteolytic processing of
amyloid precursor protein (APP) to amyloid β-peptide, the principal component of the …
amyloid precursor protein (APP) to amyloid β-peptide, the principal component of the …
Localization of voltage-gated ion channels in mammalian brain
JS Trimmer, KJ Rhodes - Annu. Rev. Physiol., 2004 - annualreviews.org
▪ Abstract The intrinsic electrical properties of neurons are shaped in large part by the action
of voltage-gated ion channels. Molecular cloning studies have revealed a large family of ion …
of voltage-gated ion channels. Molecular cloning studies have revealed a large family of ion …
Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain
CS Müller, A Haupt, W Bildl… - Proceedings of the …, 2010 - National Acad Sciences
Local Ca2+ signaling occurring within nanometers of voltage-gated Ca2+ (Cav) channels is
crucial for CNS function, yet the molecular composition of Cav channel nano-environments …
crucial for CNS function, yet the molecular composition of Cav channel nano-environments …
Membrane-associated guanylate kinases regulate adhesion and plasticity at cell junctions
L Funke, S Dakoji, DS Bredt - Annu. Rev. Biochem., 2005 - annualreviews.org
▪ Abstract Tissue development, differentiation, and physiology require specialized cellular
adhesion and signal transduction at sites of cell-cell contact. Scaffolding proteins that tether …
adhesion and signal transduction at sites of cell-cell contact. Scaffolding proteins that tether …
[HTML][HTML] Assembling the presynaptic active zone: a characterization of an active zone precursor vesicle
RG Zhai, H Vardinon-Friedman, C Cases-Langhoff… - Neuron, 2001 - cell.com
The active zone is a specialized region of the presynaptic plasma membrane where synaptic
vesicles dock and fuse. In this study, we have investigated the cellular mechanism …
vesicles dock and fuse. In this study, we have investigated the cellular mechanism …