Macrophages reside in specific territories in organs, where they contribute to the
development, homeostasis, and repair of tissues. Recent work has shown that the size of …

Centrosomal abnormalities, in particular centrosome amplification, are recurrent features of
human tumors. Enforced centrosome amplification in vivo plays a role in tumor initiation and …

Macrophages and cancer cells populations are posited to navigate basement membrane
barriers by either mobilizing proteolytic enzymes or deploying mechanical forces …

The tumour microenvironment plays a crucial role in the growth and progression of cancer,
and the presence of tumour-associated macrophages (TAMs) is associated with poor …

Recently developed human intestinal epithelial 3D organoid cultures are a useful cell
culture model to study intestinal transport physiology. From these, 2D monolayer cultures …

Background: Cathepsin L (Ctsl) is a cysteine protease mainly located within the
endosomal/lysosomal cell compartment. High expression of Ctsl indicates poor prognosis in …

Cancer cells thrive when embedded in a fine-tuned cellular and extracellular environment or
tumour microenvironment (TME). There is a general understanding of a co-evolution …

Macrophages infiltrate and remodel extracellular matrix barriers during development and
disease. Bahr and Weiss demonstrate that human macrophages remodel native basement …

There is a significant unmet need for the development of complex and scalable 3D
colorectal cancer (CRC) models. Presently, there is no known method for predicting patient …

Tumour associated macrophages (TAMs) are a highly plastic stromal cell type which are
exquisitely polarized by the tumour microenvironment (TME) to support cancer progression …