The neuronal ceroid lipofuscinoses (NCL) are a group of disorders defined by shared
clinical and pathological features, including seizures and progressive decline in vision …

The neuronal ceroid lipofuscinoses (NCLs), collectively known as Batten disease, are a
group of neurological diseases that affect all ages and ethnicities worldwide. There are 13 …

The CLN3 gene was identified over two decades ago, but the primary function of the CLN3
protein remains unknown. Recessive inheritance of loss of function mutations in CLN3 are …

ABSTRACT CLN3 disease is a lysosomal storage disorder associated with fatal
neurodegeneration that is caused by mutations in CLN3, with most affected individuals …

The NCLs (neuronal ceroid lipofuscinosis) are forms of neurodegenerative disease that
affect people of all ages and ethnicities but are most prevalent in children. Commonly known …

The neuronal ceroid lipofuscinoses (NCLs), also referred to as Batten disease, are a family
of neurodegenerative diseases that affect all age groups and ethnicities around the globe. At …

Mutations in CLN5 cause a subtype of neuronal ceroid lipofuscinosis (NCL) called CLN5
disease. While the precise role of CLN5 in NCL pathogenesis is not known, recent work …

Introduction: Neuronal ceroid lipofuscinoses (NCL) are neurodegenerative lysosomal
storage disorders typically characterized by cognitive and visual impairments, epileptic …

Contractile vacuoles (CVs), enigmatic osmoregulatory organelles, share common
characteristics, such as a requirement for RAB11 and high levels of V-ATPase. These …

Background: The incidence of neurological disorders is increasing due to population growth
and extended life expectancy. Despite advances in the understanding of these disorders …