Artificial intelligence-driven antimicrobial peptide discovery

P Szymczak, E Szczurek - Current Opinion in Structural Biology, 2023 - Elsevier
Antimicrobial peptides (AMPs) emerge as promising agents against antimicrobial resistance,
providing an alternative to conventional antibiotics. Artificial intelligence (AI) revolutionized …

Development and use of machine learning algorithms in vaccine target selection

B Bravi - npj Vaccines, 2024 - nature.com
Computer-aided discovery of vaccine targets has become a cornerstone of rational vaccine
design. In this article, I discuss how Machine Learning (ML) can inform and guide key …

Peptidebert: A language model based on transformers for peptide property prediction

C Guntuboina, A Das, P Mollaei, S Kim… - The Journal of …, 2023 - ACS Publications
Recent advances in language models have enabled the protein modeling community with a
powerful tool that uses transformers to represent protein sequences as text. This …

Therapeutic peptide development revolutionized: Harnessing the power of artificial intelligence for drug discovery

S Hashemi, P Vosough, S Taghizadeh… - Heliyon, 2024 - cell.com
Due to the spread of antibiotic resistance, global attention is focused on its inhibition and the
expansion of effective medicinal compounds. The novel functional properties of peptides …

Multi-peptide: multimodality leveraged language-graph learning of peptide properties

S Badrinarayanan, C Guntuboina… - Journal of Chemical …, 2024 - ACS Publications
Peptides are crucial in biological processes and therapeutic applications. Given their
importance, advancing our ability to predict peptide properties is essential. In this study, we …

Deep learning for advancing peptide drug development: Tools and methods in structure prediction and design

X Wu, H Lin, R Bai, H Duan - European Journal of Medicinal Chemistry, 2024 - Elsevier
Peptides can bind challenging disease targets with high affinity and specificity, offering
enormous opportunities for addressing unmet medical needs. However, peptides' unique …

Computational methods in glaucoma research: current status and future outlook

MJ Kim, CA Martin, J Kim, MM Jablonski - Molecular Aspects of Medicine, 2023 - Elsevier
Advancements in computational techniques have transformed glaucoma research, providing
a deeper understanding of genetics, disease mechanisms, and potential therapeutic targets …

Now what sequence? Pre-trained ensembles for Bayesian optimization of protein sequences

Z Yang, KA Milas, AD White - bioRxiv, 2022 - biorxiv.org
Pre-trained models have been transformative in natural language, computer vision, and now
protein sequences by enabling accuracy with few training examples. We show how to use …

Learning peptide properties with positive examples only

M Ansari, AD White - Digital Discovery, 2024 - pubs.rsc.org
Deep learning can create accurate predictive models by exploiting existing large-scale
experimental data, and guide the design of molecules. However, a major barrier is the …

Massive parallel alignment of rna-seq reads in serverless computing

P Cinaglia, JL Vázquez-Poletti… - Big Data and Cognitive …, 2023 - mdpi.com
In recent years, the use of Cloud infrastructures for data processing has proven useful, with a
computing potential that is not affected by the limitations of a local infrastructure. In this …