Artemisia annua L. is used throughout Asia and Africa as tea and press juice to treat malaria
and related symptomes (fever, chills). Its active ingredient, artemisinin (ARS), has been …

Ferroptosis is a newly described type of programmed cell death and intensively related to
both maintaining homeostasis and the development of diseases, especially cancers …

Artesunate, an anti-malarial drug, has been repurposed as an anticancer drug due to its
induction of cell death via reactive oxygen species (ROS) production. However, the …

Background Dihydroartemisinin (DHA) has been shown to exert anticancer activity through
iron-dependent reactive oxygen species (ROS) generation, which is similar to ferroptosis, a …

Oncogenic KRas reprograms pancreatic ductal adenocarcinoma (PDAC) cells to states
which are highly resistant to apoptosis. Thus, a major preclinical goal is to identify effective …

Background Apoptosis and other forms of cell death have been intensively investigated in
the past years to explain the mode of action of synthetic anticancer drugs and natural …

Artemisinins are a family of sesquiterpene trioxane lactone anti-malarial agents originally
derived from Artemisia annua L. The anti-malarial action of artemisinins involves the …

Despite international efforts to 'roll back malaria'the 2008 World Malaria Report revealed the
disease still affects approximately 3 billion people in 109 countries; 45 within the WHO …

Artemisia annua is currently the only commercial source of the sesquiterpene lactone
artemisinin. Since artemisinin was discovered as the active component of A. annua in early …

Artemisinin and its derivatives (collectively termed as artemisinins) are among the most
important and effective antimalarial drugs, with proven safety and efficacy in clinical use …