SRC homology 3 (SH3) domains are fundamental modules that enable the assembly of
protein complexes through physical interactions with a pool of proline-rich/noncanonical …

Axon growth enables the rapid wiring of the central nervous system. Understanding this
process is a prerequisite to retriggering it under pathological conditions, such as a spinal …

Dysregulation of glucose homeostasis leading to metabolic syndrome and type 2 diabetes is
the cause of an increasing world health crisis. New intriguing roles have emerged for Rho …

Redox signaling is a fundamental mechanism that controls all major biological processes
partly via protein cysteine oxidations, including S-glutathionylation. Despite over 2000 …

High-grade glioma (HGG) and glioblastoma are the most common adult malignant brain
tumors. The standard treatment consists of surgical resection followed by …

Intellectual disability (ID) is a pathological condition characterized by limited intellectual
functioning and adaptive behaviors. It affects 1–3% of the worldwide population, and no …

Simple Summary Forced molting refers to the systemic stress response of laying hens
caused by some externally imposed artificial measures (such as starvation), resulting in …

Microtubules are a major cytoskeletal component of neurites, and the regulation of
microtubule stability is essential for neurite morphogenesis. βPix (ARHGEF7) is a guanine …

The highly conserved GTPase Cdc42 is an essential regulator of cell polarity and promotes
exocytosis through the exocyst complex in budding yeast and Drosophila. In mammals, this …

Immunity is governed by successful T cell migration, optimized to enable a T cell to fully scan
its environment without wasted movement by balancing speed and turning. Here we report …