Synopsis Sevoflurane is an ether inhalation general anaesthetic agent with lower solubility
in blood than isoflurane or halothane but not desflurane. The low solubility and the absence …

Biotransformation of volatile anesthetics is of considerable interest because of known
associations between metabolism of certain anesthetics and specific organ toxicities. For …

Featuring more than 4100 references, Drug-Induced Liver Disease is an invaluable
reference for gastroenterologists, hepatologists, family physicians, internists, pathologists …

Present package labeling for sevoflurane recommends the use of fresh gas flow rates of 2
L/min or more when delivering anesthesia with sevoflurane. This recommendation resulted …

Sevoflurane is a safe and versatile inhalational anesthetic compared with currently available
agents. Sevoflurane is useful in adults and children for both induction and maintenance of …

Organ toxicity is rare in patients exposed to inhaled anesthetics, but it is of particular clinical
concern because its occurrence is highly unpredictable and because it may result in severe …

The safety of low-flow sevoflurane anesthesia, which produces higher concentrations of
toxic compounds, has been questioned. One hundred surgical patients received sevoflurane …

Kurtovic J, Riordan SM (The Prince of Wales Hospital and University of New South Wales,
Sydney, Australia). Paracetamol‐induced hepatotoxicity at recommended dosage (Case …

A substantial part of the interindividual variability in response to drugs and xenobiotics is
related to genetically-determined impairment in drug metabolism. Several drug-metabolising …

Clinical and economic factors that are important to consider when selecting anaesthesia for
day-case surgery can differ from those for inpatient anaesthesia. Patients undergoing day …