BACKGROUND Many key global sustainability challenges are closely intertwined
(examples are provided in the figure). These challenges include air pollution, biodiversity …

The most fundamental questions such as whether a cell is alive, in the sense of being able
to divide or to form a colony, may sometimes be very hard to answer, since even axenic …

Objective The goal of this study was to investigate whether clinical insomnia is associated
with immune alterations by comparing immune functioning between patients with chronic …

MCF7 human breast cancer cells have been studied extensively as a model for hormonal
effects on breast cancer cell growth and specific protein synthesis. Because the proliferative …

Methotrexate is an antifolate that is widely used in the treatment of rheumatic disorders and
malignant tumors. The efficacy of methotrexate is often limited by severe side effects and …

The efficacy of methotrexate (MTX), a widely used cytotoxic chemotherapeutic agent, is often
limited by severe side effects and toxic sequelae. Regarding the mechanisms of these side …

Objective: Depression is particularly prevalent in patients with advanced cancer. Cognitive
therapy (CT) is an empirically supported treatment for depression in the general population …

Neutrophil activation in Behcet’s disease Page 1 Neutrophil activation in Behcet’s disease E.
Eksioglu-Demiralp1, H. Direskeneli2, A. Kibaroglu1, S. Yavuz2, T. Ergun3, T. Akoglu1 …

STAT5 proteins are components of the common growth hormone and interleukin 2 family of
cytokines' signaling pathway. Mutations in the STAT5b gene, described in 2 patients, lead to …

Methotrexate (MTX), a folic acid antagonist widely used for the treatment of a variety of
tumors and inflammatory diseases, affects normal tissues that have a high rate of …