[HTML][HTML] Particle transport and deposition: basic physics of particle kinetics

A Tsuda, FS Henry, JP Butler - Comprehensive physiology, 2013 - ncbi.nlm.nih.gov
The human body interacts with the environment in many different ways. The lungs interact
with the external environment through breathing. The enormously large surface area of the …

Revisiting airflow and aerosol transport phenomena in the deep lungs with microfluidics

J Sznitman - Chemical Reviews, 2021 - ACS Publications
The dynamics of respiratory airflows and the associated transport mechanisms of inhaled
aerosols characteristic of the deep regions of the lungs are of broad interest in assessing …

Fluorescent reconstitution on deposition of PM2.5 in lung and extrapulmonary organs

D Li, Y Li, G Li, Y Zhang, J Li… - Proceedings of the …, 2019 - National Acad Sciences
The deposition of PM2. 5 (fine particulate matter in air with diameter smaller than 2.5 μm) in
lungs is harmful to human health. However, real-time observation on the deposition of …

Respiratory microflows in the pulmonary acinus

J Sznitman - Journal of biomechanics, 2013 - Elsevier
Over the past few decades, our understanding of the fluid mechanics characterizing the
pulmonary acinus of the lungs has been fundamentally revisited. In the present paper, we …

Assessment of morphometry of pulmonary acini in mouse lungs by nondestructive imaging using multiscale microcomputed tomography

DM Vasilescu, Z Gao, PK Saha, L Yin… - Proceedings of the …, 2012 - National Acad Sciences
Establishing the 3D architecture and morphometry of the intact pulmonary acinus is an
essential step toward a more complete understanding of the relationship of lung structure …

Particle dynamics and deposition in true-scale pulmonary acinar models

R Fishler, P Hofemeier, Y Etzion, Y Dubowski… - Scientific Reports, 2015 - nature.com
Particle transport phenomena in the deep alveolated airways of the lungs (ie pulmonary
acinus) govern deposition outcomes following inhalation of hazardous or pharmaceutical …

Revisiting pulmonary acinar particle transport: convection, sedimentation, diffusion, and their interplay

P Hofemeier, J Sznitman - Journal of Applied Physiology, 2015 - journals.physiology.org
It is largely acknowledged that inhaled particles ranging from 0.001 to 10 μm are able to
reach and deposit in the alveolated regions of the lungs. To date, however, the bulk of …

Multiscale image‐based modeling and simulation of gas flow and particle transport in the human lungs

CL Lin, MH Tawhai, EA Hoffman - … Reviews: Systems Biology …, 2013 - Wiley Online Library
Improved understanding of structure and function relationships in the human lungs in
individuals and subpopulations is fundamentally important to the future of pulmonary …

Modeling airflow and particle deposition in a human acinar region

AV Kolanjiyil, C Kleinstreuer - Computational and mathematical …, 2019 - Wiley Online Library
The alveolar region, encompassing millions of alveoli, is the most vital part of the lung.
However, airflow behavior and particle deposition in that region are not fully understood …

Computational modeling of aerosol transport, dispersion, and deposition in rhythmically expanding and contracting terminal alveoli

K Talaat, J Xi - Journal of Aerosol Science, 2017 - Elsevier
Inhalation dosimetry in the alveolar region is critical in assessing health risks of inhaled
toxicants and therapeutic outcomes of systemic pulmonary drug delivery. Most previous …