The gastrointestinal tract is an immunologically rich organ, containing complex cell networks
and dense lymphoid structures that safeguard this large absorptive barrier from pathogens …

The thymus is the organ responsible for T cell development and the formation of the
adaptive immunity function. Its multicellular environment consists mainly of the different …

Innate lymphoid cells (ILCs) are guardians of mucosal immunity, yet the transcriptional
networks that support their function remain poorly understood. We used inducible …

The generation of lymphoid tissues during embryogenesis relies on group 3 innate lymphoid
cells (ILC3) displaying lymphoid tissue inducer (LTi) activity and expressing the master …

Mammalian innate lymphoid cells (ILCs) have functional relevance under both homeostatic
and disease settings, such as inflammatory bowel disease (IBD), particularly in the context of …

Full development of IL-17 producing CD4+ T helper cells (TH17 cells) requires the
transcriptional activity of both orphan nuclear receptors RORα and RORγt. However, RORα …

Innate lymphoid cells (ILCs) are heterogeneous innate immune cells which participate in
host defense, mucosal repair and immunopathology by producing effector cytokines …

Innate lymphoid cells (ILCs) are a recently identified subset of leukocytes that play a central
role in pathogen surveillance and resistance, modulation of immune response, and tissue …

Innate lymphoid cells (ILCs) and macrophages are tissue-resident cells that play important
roles in tissue-immune homeostasis and immune regulation. ILCs are mainly distributed on …

The discovery of innate lymphoid cells (ILCs) has revolutionized our understanding of innate
immunity and immune cell interactions at epithelial barrier sites. Their presence and …