Heart contraction vitally depends on tightly controlled intracellular Ca regulation. Because
contraction is mainly driven by Ca released from the sarcoplasmic reticulum (SR), this …

The ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the
sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple …

The most common cardiac pathologies, such as myocardial infarction and heart failure, are
associated with oxidative stress. Oxidation of the cardiac ryanodine receptor (RyR2) Ca2+ …

Calcium signaling plays an important role in cell survival by influencing mitochondria-related
processes such as energy production and apoptosis. The endoplasmic reticulum (ER) is the …

The two major calcium (Ca 2+) release channels on the sarco/endoplasmic reticulum
(SR/ER) are inositol 1, 4, 5-trisphosphate and ryanodine receptors (IP 3 Rs and RyRs). They …

Transient receptor potential vanilloid 1 (TRPV1) channel is a tetrameric protein that acts as a
sensor for noxious stimuli such as heat and for diverse inflammatory mediators such as …

Abstract Type 2 ryanodine receptor (RyR2) serves as the major intracellular Ca 2+ release
channel that drives heart contraction. RyR2 is activated by cytosolic Ca 2+ via the process of …

Calcium release from internal stores is a quintessential event in excitation-contraction
coupling in cardiac and skeletal muscle. The ryanodine receptor Ca 2+ release channel is …

Human ryanodine receptor 2 (hRyR2) mediates calcium release from the sarcoplasmic
reticulum, enabling cardiomyocyte contraction. The N-terminal region of hRyR2 (amino …

The type 2 ryanodine receptor (RyR2) plays a key role in the cardiac intracellular calcium
(Ca 2+) regulation. We have previously shown that oxidative stress activates RyR2 in rabbit …