Cell migration is a highly dynamic process driven by the cytoskeleton, which mainly
comprises the actin microfilaments, microtubules, and intermediate filaments. During …

Microtubules control cell architecture by serving as a scaffold for intracellular transport,
signaling, and organelle positioning. Microtubules are intrinsically polarized, and their …

The centrosome is the main organizer of microtubules and as such, its position is a key
determinant of polarized cell functions. As the name says, the default position of the …

Simple Summary Cell migration is crucial fReaor metastasis formation and a hallmark of
malignancy. The primary cause of high mortality among oncology patients is the ability of …

The microtubule cytoskeleton has a well-established, instrumental role in coordinating cell
migration. Decades of research has focused on understanding how microtubules couple …

The centrosome, consisting of centrioles and the associated pericentriolar material, is the
main microtubule-organizing centre (MTOC) in animal cells. During most of interphase, the …

Bundled with various kinds of adhesion molecules and anchored to the basement
membrane, the epithelium has historically been considered as an immotile tissue and, to …

Cell polarity is important for controlling cell shape, motility and cell division processes.
Vimentin intermediate filaments are important for cell migration and cell polarization in …

In vitro experiments have shown that cell scale curvatures influence cell migration; cells
avoid convex hills and settle in concave valleys. However, it is not known whether dynamic …

Cell polarity regulators are ubiquitous, evolutionary conserved multifunctional proteins. They
contain a variety of protein–protein interaction domains endowing them the capacity to …