Demand-adjusted and cell type specific rates of protein synthesis represent an important
safeguard for fate and function of long-term hematopoietic stem cells. Here, we identify …

Many inherited bone marrow failure syndromes (IBMFSs) present a high risk of
transformation to myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) …

Fanconi anemia (FA) is generally classified as a DNA repair disorder, conferring a genetic
predisposition to cancer and prominent bone marrow failure (BMF) in early childhood …

RAD51 is an indispensable homologous recombination protein, necessary for strand
invasion and crossing over. It has recently been designated as a Fanconi anemia (FA) gene …

Fanconi anemia (FA) is a disorder of DNA repair that manifests as bone marrow (BM) failure.
The lack of accurate murine models of FA has refocused efforts toward differentiation of …

Fanconi anemia (FA) is a rare human genetic disorder characterized by bone marrow
failure, predisposition to cancer and developmental defects including hypogonadism …

Fanconi anemia (FA) causes bone marrow failure early during childhood, and recent studies
indicate that a hematopoietic defect could begin in utero. We performed a unique kinetics …

Fanconi Anemia (FA) is an inherited bone marrow (BM) failure disorder commonly
diagnosed during school age. However, in murine models, disrupted function of FA genes …

Highlights•Inherited bone marrow failure syndromes reveal distinct hematopoietic defects
during development.•Murine, zebrafish. and induced pluripotent stem cell models have been …

Bone marrow failure (BMF) in Fanconi Anemia (FA) results from exhaustion of hematopoietic
stem cells (HSC), but the physiological role of FA proteins in HSC pool integrity remains …