The JAK/STAT signaling pathway plays a key role in cytokine signaling and is involved in
development, immunity, and tumorigenesis for nearly any cell. At first glance, the JAK/STAT …

The Signal Transducer and Activator of Transcription (STAT)-5 proteins are required in
immune regulation and homeostasis and play a crucial role in the development and function …

With the introduction of large-scale molecular profiling methods and high-throughput
sequencing technologies, the genomic features of most lymphoid neoplasms have been …

Large granular lymphocyte (LGL) leukemia comprises a group of rare lymphoproliferative
disorders whose molecular landscape is incompletely defined. We leveraged paired whole …

Large granular lymphocyte (LGL) leukemia has been recognized in the World Health
Organization classifications among mature T cell and natural killer cell neoplasms and is …

Chronic natural killer large granular lymphocyte (NK-LGL) leukemia, also referred to as
chronic lymphoproliferative disorder of NK cells, is a rare disorder defined by prolonged …

Large granular lymphocyte leukemia (LGLL) is a rare and chronic lymphoproliferative
disorder characterized by the clonal expansion of LGLs. LGLL patients can be asymptomatic …

CD4+ T-cell large granular lymphocyte leukemia (T-LGLL) is a rare subtype of T-LGLL with
unknown etiology. In this study, we molecularly characterized a cohort of patients (n= 35) by …

Signal transducer and activator of transcription 3 (STAT3) is an important and the most
studied transcription factor in the Janus kinase (JAK)/STAT signaling pathway. STAT3 …

Hyper-activated STAT5B variants are high value oncology targets for pharmacologic
intervention. STAT5BN642H, a frequently-occurring oncogenic driver mutation, promotes …