At a time when complex diseases affect globally 280 million people and claim 14 million
lives every year, there is an urgent need to rapidly increase our knowledge into their …

Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system and
the association with other autoimmune diseases is well-documented. There are many …

Introduction Many chronic disorders have genomic etiology, disease progression, clinical
presentation, and response to treatment that vary on a patient-to-patient basis. Such …

A personalized approach is strongly advocated for treatment selection in Multiple Sclerosis
patients due to the high number of available drugs. Machine learning methods proved to be …

From the perspective of precision medicine, the challenge for the future is to improve the
accuracy of diagnosis, prognosis, and prediction of therapeutic responses through the …

In the last few decades, the prevalence of multiple sclerosis (MS), a chronic inflammatory
disease of the nervous system, has increased, particularly in Northern European countries …

In recent years, the study of single nucleotide polymorphisms (SNPs) has gained increasing
importance in biomedical research, as they can either be at the molecular origin of a …

Human regulatory CD4+ T cells (Tregs) are potent immunosuppressive lymphocytes
responsible for immune tolerance and homeostasis. Since the seminal reports identifying …

For many years, a considerable number of patients with autoimmune diseases (ADs) have
suffered from a lack of drug response and drug‐related toxicity. Despite the emergence of …

Background: Over the past two decades, various novel disease-modifying drugs for multiple
sclerosis (MS) have been approved. However, there is high variability in the patient …