1.1. Background During exercise and with exposure to hot climatic conditions, there is
tendency for the human body to store heat and for body temperatures to rise. Changes in …

Pharmacological agents used to treat or manage diseases can modify the level of heat strain
experienced by chronically ill and elderly patients via different mechanistic pathways …

The erratic, intermittent, and unpredictable nature of sweat production, resulting from
physiological or psychological fluctuations, poses intricacies to consistently and accurately …

In humans, sweating is the most powerful autonomic thermoeffector. The evaporation of
sweat provides by far the greatest potential for heat loss and it represents the only means of …

Nitric oxide synthase (NOS) contributes to sweating and cutaneous vasodilation during
exercise in younger adults. We hypothesized that endothelial NOS (eNOS) and neuronal …

Many studies have aimed to identify the controllers of sweating using ventilated capsules
with intradermal microdialysis. It is unclear, however, if the surface area covered by the …

Transient receptor potential vanilloid 4 (TRPV4) channels exist in the endothelial cells of
cutaneous blood vessels and the secretory cells of eccrine sweat glands. We assessed if …

Abstract Acute dietary nitrate (NO 3−) supplementation can increase [NO 3−], but not nitrite
([NO 2−]), in human skeletal muscle, though its effect on [NO 3−] and [NO 2−] in skin remains …

Key points Studies show that nitric oxide synthase (NOS) and cyclooxygenase (COX) are
involved in sweating and cutaneous vascular regulation in young adults in a potentially …

Key points Nitric oxide synthase (NOS) contributes to sweating and cutaneous
vasodilatation during exercise in the heat. Similarly, reports show that Na+/K+‐ATPase …