Data-driven computational models of neurons, synapses, microcircuits, and mesocircuits
have become essential tools in modern brain research. The goal of these multiscale models …

Structural rules underlying functional properties of cortical circuits are poorly understood. To
explore these rules systematically, we integrated information from extensive literature …

Understanding the activity of the mammalian brain requires an integrative knowledge of
circuits at distinct scales, ranging from ion channel gating to circuit connectomics …

Stimulus size modulation of neuronal firing activity is a fundamental property of the primary
visual cortex. Numerous biological experiments have shown that stimulus size modulation is …

A biophysically detailed description of the mechanisms of the primary vision is still being
developed. We have incorporated a simplified, filter-based description of retino-thalamic …

The spatial organization and dynamic interactions between excitatory and inhibitory synaptic
inputs that define the receptive field (RF) of simple cells in the cat primary visual cortex (V1) …

A fundamental challenge for the theoretical study of neuronal networks is to make the link
between complex biophysical models based directly on experimental data, to progressively …

The cerebral cortex exhibits a sophisticated neural architecture across its six layers.
Recently, it was found that these layers exhibit different ratios of excitatory to inhibitory (EI) …

Neurons in the primary visual cortex (V1) are classically thought to encode spatial features
of visual stimuli through simple population codes: each neuron exhibits a preferred …

Biological experiments targeting the mammalian primary visual cortex have shown that
neuronal response to a preferred orientation grating is cross-inhibited by an orthogonal …