5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

Depression is a polygenic and highly complex psychiatric disorder that remains a major
burden on society. Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) …

Clinical studies indicate that cannabidiol (CBD), the primary nonaddictive component of
cannabis that interacts with the serotonin (5-HT) 1A receptor, may possess analgesic and …

Current medication for anxiety disorders is suboptimal in terms of efficiency and tolerability,
highlighting the need for improved drug treatments. In this review an overview of drugs …

Aggression and violence represent a significant public health concern and a clinical
challenge for the mental healthcare provider. A great deal has been revealed regarding the …

Acute sleep deprivation (ASD) is often observed in shift workers and characterized by
drowsiness and unrelenting exhaustion. The physiological and psychological effects of ASD …

Since our review of central 5-HT receptors and their function twenty years ago, no new 5-HT
receptor has been discovered and there is little evidence that this situation will change in the …

Decreased serotonergic activity has been implicated in anxiety and major depression, and
antidepressants directly or indirectly increase the long-term activity of the serotonin system …

The neurotransmitter serotonin is an evolutionary ancient molecule that has remarkable
modulatory effects in almost all central nervous system integrative functions, such as mood …

The 5-HT1A receptor is highly expressed both in 5-HT neurons as a presynaptic inhibitory
autoreceptor, and in many brain regions innervated by 5-HT as a post-synaptic …