A fundamental metabolic feature of cancerous tissues is high glucose consumption. The rate
of glucose consumption in a cancer cell can be 10–15 times higher than in normal cells …

Mitochondria are dynamic organelles vital for energy production with now appreciated roles
in immune defense. During microbial infection, mitochondria serve as signaling hubs to …

Metformin is a widely used and well-tolerated anti-diabetic drug that can reduce cancer risk
and improve the prognosis of certain malignancies. However, the mechanism underlying its …

The relative contribution of mitochondrial respiration and subsequent energy production in
malignant cells has remained controversial to date. Enhanced aerobic glycolysis and …

Aims/hypothesis Metformin is increasingly used therapeutically during pregnancy
worldwide, particularly in the treatment of gestational diabetes, which affects a substantial …

Epithelial-mesenchymal transition (EMT), which is mainly recognized by upregulation of
mesenchymal markers and movement of cells, is a critical stage occurred during embryo …

Loss of protein homeostasis is a hallmark of the aging process. We and others have
previously shown that maintenance of proteostasis is a shared characteristic of slowed …

The clinically approved drug metformin has been shown to selectively kill persister cancer
cells through mechanisms that are not fully understood. To provide further mechanistic …

The fact that mitochondria play a crucial part in energy generation has led to the nickname
“powerhouses” of the cell being applied to them. They also play a significant role in many …

A major goal of cancer research is the identification of tumor-specific vulnerabilities that can
be exploited for the development of therapies that are selectively toxic to the tumor. We show …