It is puzzling that hydrogen-rich fatty acids are used only poorly as fuel in the brain. The long-
standing belief that a slow passage of fatty acids across the blood–brain barrier might be the …

Hypertension is one of the major risk factors of cardiovascular diseases, but despite a
century of clinical and basic research, the discrete etiology of this disease is still not fully …

Ageing is accompanied by increasing vulnerability to major pathologies (atherosclerosis,
Alzheimer's disease, age-related macular degeneration, cataract, and osteoporosis) which …

Peroxisomes contain numerous enzymatic activities that are important for mammalian
physiology. Patients lacking either all peroxisomal functions or a single enzyme or …

Currently the molecular basis for the clinical heterogeneity of X-linked
adrenoleukodystrophy (X-ALD) is poorly understood. The genetic bases for all different …

Mitochondrial dysfunction and oxidative stress have been implicated in the pathogenesis of
a number of diseases and conditions. Oxidative stress occurs once the antioxidant defenses …

Oxysterols are the products of cholesterol oxidation. They have a wide range of effects on
several cells, organs, and systems in the body. Oxysterols also have an influence on the …

A systematic, rational search for chalcone derivatives with multifunctional behavior has been
carried out, with the support of a computer-assisted protocol (CADMA-Chem). A total of 568 …

The consumption of marine fishes and general seafood has long been recommended by
several medical authorities as a long-term nutritional intervention to preserve mental health …

Oligodendrocytes are the primary target of demyelinating disorders, and progressive
neurodegenerative changes may evolve in the CNS. DNA damage and oxidative stress are …