Hepatotoxicity of monoterpenes and sesquiterpenes

T Zárybnický, I Boušová, M Ambrož, L Skálová - Archives of Toxicology, 2018 - Springer
Public interest in natural therapies has increased significantly over past decades. Herbs and
herbal products are extensively consumed worldwide and they are generally considered as …

An Overview: The Toxicity of Ageratina adenophora on Animals and Its Possible Interventions

Z Ren, SK Okyere, J Wen, L Xie, Y Cui, S Wang… - International Journal of …, 2021 - mdpi.com
Ageratina adenophora is one of the major invasive weeds that causes instability of the
ecosystem. Research has reported that A. adenophora produces allelochemicals that inhibit …

Ageratina adenophora Disrupts the Intestinal Structure and Immune Barrier Integrity in Rats

Y Cui, SK Okyere, P Gao, J Wen, S Cao, Y Wang… - Toxins, 2021 - mdpi.com
The aim of this study was to investigate the effects of Ageratina adenophora on the intestines
morphology and integrity in rat. Rats were randomly divided into two groups and were fed …

Ageratina adenophora induces mice hepatotoxicity via ROS-NLRP3-mediated pyroptosis

W Sun, C Zeng, S Liu, J Fu, L Hu, Z Shi, D Yue… - Scientific Reports, 2018 - nature.com
Increasing evidences have demonstrated that Ageratina adenophora (A. adenophora) can
cause hepatotoxicity of animals. Liver is an important site in immune regulation and …

Toxic mechanisms and pharmacological properties of euptox A, a toxic monomer from A. adenophora

SK Okyere, J Wen, Y Cui, L Xie, P Gao, J Wang… - Fitoterapia, 2021 - Elsevier
Abstract A. adenophora (Spreng.) RM King & H. Rob. is as invasive plant known to cause
toxicity in humans and animals. The plant's toxic activities have been associated with some …

Ageratina adenophora Inhibits Spleen Immune Function in Rats via the Loss of the FRC Network and Th1–Th2 Cell Ratio Elevation

Z Ren, P Gao, SK Okyere, Y Cui, J Wen, B Jing, J Deng… - Toxins, 2021 - mdpi.com
The objective of this study was to determine the impact of Ageratina adenophora (A.
adenophora) on splenic immune function in a rat model. Rats were fed with 10 g/100 g …

Euptox A Induces G0/GI arrest and apoptosis of hepatocyte via ROS, mitochondrial dysfunction and caspases-dependent pathways in vivo

SK Okyere, Q Mo, G Pei, Z Ren, J Deng… - The Journal of …, 2020 - jstage.jst.go.jp
As a toxin of Ageratina adenophora (A. adenophora), euptox A (9-oxo-10, 11-
dehydroageraphorone) is known to cause hepatotoxicity in animals. In this study, we …

Ageratina adenophora causes spleen toxicity by inducing oxidative stress and pyroptosis in mice

W Sun, C Zeng, D Yue, S Liu, Z Ren… - Royal Society …, 2019 - royalsocietypublishing.org
Ageratina adenophora is an invasive weed with potent toxicological effects on livestock.
Oxidative stress and pyroptosis play a pivotal role in regulating animal or human health and …

Toxicity Assessment of Cadinene Sesquiterpenes from Eupatorium adenophorum in Mice

CB Ouyang, XM Liu, Q Liu, J Bai, HY Li, Y Li… - Natural products and …, 2015 - Springer
This study evaluated toxic efficacy of Eupatorium adenophorum extracts, against the
Kunming mice. In acute study, we firstly tested median lethal dose (LD 50) in mice of three …

[HTML][HTML] Hepatotoxicity effects of Ageratina adenophora, as indicated by network toxicology combined with metabolomics and transcriptomics

R Huang, SK Okyere, C Shao, M Yousif, F Liao… - Ecotoxicology and …, 2023 - Elsevier
Abstract Ageratina adenophora (A. adenophora), one of the prominent invasive plants in the
Asian continent has shown toxicity in animals. However, studies examining the gene …