Most neurodegenerative diseases are characterized by the intracellular or extracellular
aggregation of misfolded proteins such as amyloid-β and tau in Alzheimer disease, α …

As the crucial powerhouse for cell metabolism and tissue survival, the mitochondrion
frequently undergoes morphological or positional changes when responding to various …

Parkinson's disease (PD) is the most common movement disorder, with resting tremor,
rigidity, bradykinesia and postural instability being major symptoms. Neuropathologically, it …

Soluble α-synuclein aggregates varying in size, structure, and morphology have been
closely linked to neuronal death in Parkinson's disease. However, the heterogeneity of …

Synucleinopathies, which include multiple system atrophy (MSA), Parkinson's disease,
Parkinson's disease with dementia and dementia with Lewy bodies (DLB), are human …

Parkinson's disease, the most common age-related movement disorder, is a progressive
neurodegenerative disease with unclear etiology. Key neuropathological hallmarks are …

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by
degeneration of the substantia nigra pars compacta and by accumulation of α-synuclein in …

Microglia represent a specialized population of macrophages-like cells in the central
nervous system (CNS) considered immune sentinels that are capable of orchestrating a …

Parkinson's disease (PD) is a common neurodegenerative disorder. While a number of
nonmotor manifestations arise, the typical clinical features involve a movement disorder …

The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …