Increased availability of high-throughput technologies has generated an ever-growing
number of omics data that seek to portray many different but complementary biological …

A number of environmental factors have been associated with the development of IBD.
Alteration of the gut microbiota, or dysbiosis, is closely linked to initiation or progression of …

Motivation In the continuously expanding omics era, novel computational and statistical
strategies are needed for data integration and identification of biomarkers and molecular …

While cost-effective high-throughput technologies provide an increasing amount of data, the
analyses of single layers of data seldom provide causal relations. Multi-omics data …

Crohn's disease and ulcerative colitis are prototypical complex diseases characterized by
chronic and heterogeneous manifestations, induced by interacting environmental, genomic …

High-throughput technologies have been used to generate a large amount of omics data. In
the past, single-level analysis has been extensively conducted where the omics …

Metabolomics deals with multiple and complex chemical reactions within living organisms
and how these are influenced by external or internal perturbations. It lies at the heart of …

Biological systems function through complex interactions between various 'omics
(biomolecules), and a more complete understanding of these systems is only possible …

The study of the microbial community—the microbiome—associated with a human host is a
maturing research field. It is increasingly clear that the composition of the human's …

Mediation analysis investigates the intermediate mechanism through which an exposure
exerts its influence on the outcome of interest. Mediation analysis is becoming increasingly …