Brain metastases are the most common intracranial tumors and occur in 20–40% of all
cancer patients. Lung cancer, breast cancer, and melanoma are the most frequent primary …

Radiotherapy is highly effective due to its ability to physically focus the treatment to target the
tumor while sparing normal tissue and its ability to be combined with systemic therapy. This …

Long noncoding RNAs (lncRNAs) play essential roles in the development and progression
of many cancers. However, the contributions of lncRNAs to medulloblastoma (MB) remain …

Although external beam radiotherapy (xRT) is commonly used to treat central nervous
system (CNS) tumors in patients of all ages, young children treated with xRT frequently …

Sonic Hedgehog (SHH) signaling at primary cilia drives the proliferation and progression of
a subset of medulloblastomas, the most common malignant paediatric brain tumor. Severe …

Purpose Predicting the efficacy of radiotherapy in individual patients has drawn widespread
attention, but the limited sample size remains a bottleneck for utilizing high-dimensional …

We show that inactivating AMPK in a genetic medulloblastoma model depletes tumor stem
cells and slows progression. In medulloblastoma, the most common malignant pediatric …

It is unclear why medulloblastoma patients receiving similar treatments experience different
outcomes. Transcriptomic profiling identified subgroups with different prognoses, but in each …

Cerebellar development requires regulated proliferation of cerebellar granule neuron
progenitors (CGNPs). Inadequate CGNP proliferation causes cerebellar hypoplasia …

Abstract We show that Polycomb Repressive Complex-2 (PRC2) components EED and
EZH2 maintain neural identity in cerebellar granule neuron progenitors (CGNPs) and SHH …