Atrial fibrillation and cardiac fibrosis

C Sohns, NF Marrouche - European heart journal, 2020 - academic.oup.com
The understanding of atrial fibrillation (AF) evolved from a sole rhythm disturbance towards
the complex concept of a cardiomyopathy based on arrhythmia substrates. There is …

Left atrial voltage mapping: defining and targeting the atrial fibrillation substrate

I Sim, M Bishop, M O'Neill, SE Williams - Journal of Interventional Cardiac …, 2019 - Springer
Low atrial endocardial bipolar voltage, measured during catheter ablation for atrial
fibrillation (AF), is a commonly used surrogate marker for the presence of atrial fibrosis. Low …

Extent and spatial distribution of left atrial arrhythmogenic sites, late gadolinium enhancement at magnetic resonance imaging, and low-voltage areas in patients with …

J Chen, T Arentz, H Cochet, B Müller-Edenborn… - EP …, 2019 - academic.oup.com
Aims Atrial fibrosis contributes to arrhythmogenesis in atrial fibrillation and can be detected
by MRI or electrophysiological mapping. The current study compares the spatial correlation …

Dynamic atrial substrate during high-density mapping of paroxysmal and persistent AF: implications for substrate ablation

GR Wong, CJ Nalliah, G Lee, A Voskoboinik… - JACC: Clinical …, 2019 - jacc.org
Objectives: This study sought to determine the impact of rate and direction on left atrial (LA)
substrate. Background: The extent to which substrate mapped in sinus rhythm varies …

Multiple factors influence the morphology of the bipolar electrogram: An in silico modeling study

M Hwang, J Kim, B Lim, JS Song, B Joung… - PLoS computational …, 2019 - journals.plos.org
Although bipolar electrograms (Bi-egms) are commonly used for catheter mapping and
ablation of cardiac arrhythmias, the accuracy and reproducibility of Bi-egms have not been …

OpenEP: a cross-platform electroanatomic mapping data format and analysis platform for electrophysiology research

SE Williams, CH Roney, A Connolly, I Sim… - Frontiers in …, 2021 - frontiersin.org
Background Electroanatomic mapping systems are used to support electrophysiology
research. Data exported from these systems is stored in proprietary formats which are …

Fully automatic atrial fibrosis assessment using a multilabel convolutional neural network

O Razeghi, I Sim, CH Roney, R Karim… - Circulation …, 2020 - Am Heart Assoc
Background: Pathological atrial fibrosis is a major contributor to sustained atrial fibrillation.
Currently, late gadolinium enhancement (LGE) scans provide the only noninvasive estimate …

Intra-and interatrial conduction abnormalities: hemodynamic and arrhythmic significance

N Johner, M Namdar, DC Shah - Journal of Interventional Cardiac …, 2018 - Springer
Alterations of normal intra-and interatrial conduction are a common outcome of multiple
cardiovascular conditions. They arise most commonly in the context of advanced age …

The effect of activation rate on left atrial bipolar voltage in patients with paroxysmal atrial fibrillation

SE Williams, N Linton, L O'Neill… - Journal of …, 2017 - Wiley Online Library
Introduction Bipolar voltage is used during electroanatomic mapping to define abnormal
myocardium, but the effect of activation rate on bipolar voltage is not known. We …

CArdiac MagnEtic resonance assessment of bi-Atrial fibrosis in secundum atrial septal defects patients: CAMERA-ASD study

L O'Neill, I Sim, D O'Hare, J Whitaker… - European Heart …, 2022 - academic.oup.com
Aims Atrial septal defects (ASD) are associated with atrial arrhythmias, but the arrhythmia
substrate in these patients is poorly defined. We hypothesized that bi-atrial fibrosis is present …