Alzheimer's disease (AD) is the most common neurodegenerative disease. Pathological
proteins of AD mainly contain amyloid-beta (Aβ) and tau. Their deposition will lead to neuron …

Amyloid-β (Aβ) plaques are a key histopathological hallmark of Alzheimer's disease (AD),
and soluble Aβ species are believed to play an important role in the clinical development of …

The discovery of the water specific channel, aquaporin, and abundant expression of its
isoform, aquaporin-4 (AQP-4), on astrocyte endfeet brought about significant advancements …

The central nervous system is highly dependent on water, and disturbances in water
homeostasis can have a significant impact on its normal functions. The regulation of water …

Patients with Alzheimer's disease (AD) undergo a slowing of waking
electroencephalographic (EEG) rhythms since prodromal stages, which could be ascribed to …

The unique properties of brain capillary endothelium, critical in maintaining the blood-brain
barrier (BBB) and restricting water permeability across the BBB, have important …

Aquaporin 1 (AQP1), expressed in epithelial cells of the choroid plexus, and aquaporin 4
(AQP4) present in ependymal cells and glia limitants have been proposed to play a …

Cerebrospinal fluid (CSF) plays an essential role in maintaining the homeostasis of the
central nervous system. The functions of CSF include:(1) buoyancy of the brain, spinal cord …

Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating cerebrovascular disease
with high mortality and morbidity. In recent years, a large number of studies have focused on …

Here we evaluated the utility of MRI to monitor intrathecal infusions in nonhuman primates.
Adeno-associated virus (AAV) spiked with gadoteridol, a gadolinium-based MRI contrast …