Antibiotics changed medical practice by significantly decreasing the morbidity and mortality
associated with bacterial infection. However, infectious diseases remain the leading cause …

The world is running out of antibiotics. Between 1940 and 1962, more than 20 new classes
of antibiotics were marketed. Since then, only two new classes have reached the market …

The causes of antibiotic resistance are complex and include human behaviour at many
levels of society; the consequences affect everybody in the world. Similarities with climate …

Cheap transition metal Ni-catalyzed asymmetric hydrogenation of 2-oxazolones was
successfully developed, which provided an efficient synthetic strategy to prepare various …

The oxazolidinones are a new and potent class of antimicrobial agents with activity mainly
against Gram-positive strains. The commercial success of linezolid, the only FDA-approved …

Abstract α, α-Disubstituted α-amino acids (α-AAs) have improved properties compared to
other types of amino acids. They serve as modifiers of peptide conformation and as …

C-5-substituted triazole-oxazolidinones were synthesized using a bromide catalyzed
cycloaddition between aryl isocyanates and epibromohydrin followed by a three-component …

Nitrofuranyl isoxazolines with increased proteolytic stability over nitrofuranyl amides were
designed and synthesized leading to discovery of several compounds with potent in vitro …

The incorporation of CO 2 into substrates containing alcohol or amine functional groups
displays interesting substrate-controlled reactivity, both in terms of providing milder reaction …

Chemical fixation of CO2 is investigated by using heterogeneous catalysts (CNT-NHC-M
and GN-NHC-M; M= Ag, Cu) of N-heterocyclic carbene (NHC)–silver complex and NHC …