Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and
response. Of 57 putatively functional human CYPs only about a dozen enzymes, belonging …

Cytochrome P450 2B6 (CYP2B6) belongs to the minor drug metabolizing P450s in human
liver. Expression is highly variable both between individuals and within individuals, owing to …

An accurate assessment of how quantum computers can be used for chemical simulation,
especially their potential computational advantages, provides important context on how to …

Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …

Amphiphile selection is a critical step for structural studies of membrane proteins (MPs). We
have developed a family of steroid-based facial amphiphiles (FAs) that are structurally …

The adverse effects to humans and environment of only few chemicals are well known.
Absorption, distribution, metabolism, and excretion (ADME) are the steps of pharmaco …

The dynamic nature of protein structures has been recognized, established, and accepted
as an intrinsic fundamental property with major consequences to their function. Nowadays …

X-ray crystal structures are available for 29 eukaryotic microsomal, chloroplast, or
mitochondrial cytochrome P450s, including two non-monooxygenase P450s. These …

Abstract Cytochrome P450 (CYP) 2B6 belongs to the set of important hepatic drug-
metabolizing CYPs. It makes up roughly 3%–6% of total hepatic CYP content and …

Activities of xenobiotic-metabolizing enzymes have been measured with various in vitro and
in vivo methods, such as spectrophotometric, fluorometric, mass spectrometric, and …