Abstract Iron–sulfur (Fe–S) clusters are versatile protein cofactors that require numerous
components for their synthesis and insertion into apoproteins. In eukaryotes, maturation of …

Iron accumulation and neuroinflammation are pathological conditions found in several
neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease …

Objective: Epigenetic variation may contribute to the development of complex metabolic
diseases such as type 2 diabetes (T2D). Hepatic insulin resistance is a hallmark of T2D …

Significance: Cancer cells accumulate high levels of iron and reactive oxygen species
(ROS) to promote their high metabolic activity and proliferation rate. However, high levels of …

The development of chemotherapy drugs has promoted anticancer treatment, but the effect
on tumours is not clear because of treatment resistance; thus, it is necessary to further …

Mitochondria have been derived from alpha-bacterial endosymbionts during the evolution of
eukaryotes. Numerous bacterial functions have been maintained inside the organelles …

A novel family of 2Fe–2S proteins, the NEET family, was discovered during the last decade
in numerous organisms, including archea, bacteria, algae, plant and human; suggesting an …

MitoNEET is an outer mitochondrial membrane protein essential for sensing and regulation
of iron and reactive oxygen species (ROS) homeostasis. It is a key player in multiple human …

Mitochondrial inner NEET (MiNT) and the outer mitochondrial membrane (OMM) mitoNEET
(mNT) proteins belong to the NEET protein family. This family plays a key role in …

Neural tissue is one of the main oxygen consumers in the mammalian body, and a
plentitude of metabolic as well as signaling processes within the brain is accompanied by …