One of the most relevant achievements of Professor Gianni Bonadonna was the
implementation of the methodology of controlled clinical trials in medical oncology. It is valid …

Background: Prostate cancer (PCa) is the second most common cancer in men, and
radiotherapy (RT) is one of the main treatment options. Although effective, RT can cause …

Background and purpose Segmentation of intra-prostatic urethra for dose assessment from
planning CT may help explaining urinary toxicity in prostate cancer radiotherapy. This work …

Methionine is an essential amino acid needed for a variety of processes in living organisms.
Ionizing radiation depletes tissue methionine concentrations and leads to the loss of DNA …

Background Organ‐at‐risk (OAR) sparing is often assessed using an overlap volume‐based
parameter, defined as the ratio of the volume of OAR that overlaps the planning target …

Aim To report long-term data regarding biochemical control and late toxicity of simultaneous
integrated boost intensity modulated radiotherapy (SIB-IMRT) with tomotherapy in patients …

Background: Benign prostatic hyperplasia (BPH) is a common disease among older men
and many patients with prostate cancer (PC) also have BPH. External beam radiation …

Methionine is an essential amino acid needed for a variety of processes in living organisms.
Ionizing radiation depletes tissue methionine concentrations and leads to the loss of DNA …

CONTENTS Introduction..........................................................................................................................
...... 113 Clinical Significance of the Injury …

The term “urinary toxicity” comprises a wide variety of symptoms–including urinary
frequency, obstruction and stricture, haematuria, dysuria or incontinence–with very different …