Altered metabolism is a hallmark of cancer, and the reprogramming of energy metabolism
has historically been considered a general phenomenon of tumors. It is well recognized that …

With the development of proteomics and epigenetics, a large number of RNA‐binding
proteins (RBPs) have been discovered in recent years, and the interaction between long …

Background As a rate‐limiting enzyme of glycolysis, pyruvate kinase muscle isozyme M2
(PKM2) participates in tumor metabolism and growth. The regulatory network of PKM2 in …

Gastrointestinal (GI) tumors (cancers of the esophagus, gastric, liver, pancreas, colon, and
rectum) contribute to a large number of deaths worldwide. STAT3 is an oncogenic …

Reversible, spatial, and temporal regulation of metabolic reprogramming and epigenetic
homeostasis are prominent hallmarks of carcinogenesis. Cancer cells reprogram their …

Long non-coding RNAs (lncRNAs) play critical roles in tumorigenesis and progression of
colorectal cancer (CRC). However, functions of most lncRNAs in CRC and their molecular …

Understanding the complex and specific roles played by non-coding RNAs (ncRNAs), which
comprise the bulk of the genome, is important for understanding virtually every hallmark of …

Abstract Pyruvate kinase M2 (PKM2), a key rate-limiting enzyme of glycolysis, is a critical
regulator in tumor metabolism. PKM2 has been demonstrated to overexpressed in various …

Rationale: Non-small cell lung cancer (NSCLC) is a deadly disease with a hallmark of
aberrant metabolism. The mechanism of glycolysis associated lncRNA underlying the …

Accumulating evidence indicates that long non-coding RNAs (lncRNAs) can play a pivotal
role in regulation of diverse cellular processes. In particular, lncRNAs can serve as master …