Unveiling the role of inflammation and oxidative stress on age‐related cardiovascular diseases

AJPO de Almeida… - Oxidative medicine …, 2020 - Wiley Online Library
The global population above 60 years has been growing exponentially in the last decades,
which is accompanied by an increase in the prevalence of age‐related chronic diseases …

Control of reactive oxygen species for the prevention of Parkinson's disease: the possible application of flavonoids

TY Kim, E Leem, JM Lee, SR Kim - Antioxidants, 2020 - mdpi.com
Oxidative stress reflects an imbalance between the production of reactive oxygen species
(ROS) and antioxidant defense systems, and it can be associated with the pathogenesis and …

NFE2L2 is a potential prognostic biomarker and is correlated with immune infiltration in brain lower grade glioma: a pan‐cancer analysis

Q Ju, X Li, H Zhang, S Yan, Y Li… - Oxidative Medicine and …, 2020 - Wiley Online Library
Nuclear factor, erythroid 2 like 2 (NFE2L2, NRF2) is a transcription factor that regulates
various antioxidant enzymes. It plays a vital physiological role in regulating oxidative stress …

Molecular hybridization as a tool in the design of multi-target directed drug candidates for neurodegenerative diseases

VS Gontijo, FPD Viegas, CJC Ortiz… - Current …, 2020 - ingentaconnect.com
Neurodegenerative Diseases (NDs) are progressive multifactorial neurological pathologies
related to neuronal impairment and functional loss from different brain regions. Currently, no …

Terminators or guardians? design, synthesis, and cytotoxicity profiling of chalcone-sulfonamide hybrids

SM Aboukhatwa, PA Sidhom, A Angeli, CT Supuran… - ACS …, 2023 - ACS Publications
With a “less is more” philosophy, a series of 15 chalcone-sulfonamide hybrids were
designed anticipating synergistic anticancer activity. The aromatic sulfonamide moiety was …

Nrf2–Keap1 pathway–mediated effects of resveratrol on oxidative stress and apoptosis in hydrogen peroxide–treated rheumatoid arthritis fibroblast‐like synoviocytes

Y Zhang, G Wang, T Wang, W Cao… - Annals of the new …, 2019 - Wiley Online Library
Resveratrol (Res) is a polyphenolic compound that has a variety of biological functions and
activities. This study aimed to explore the mechanisms of the antioxidant and proapoptotic …

Targeting the Nrf2 signaling pathway using phytochemical ingredients: A novel therapeutic road map to combat neurodegenerative diseases

X Bai, Z Bian, M Zhang - Phytomedicine, 2023 - Elsevier
Background Nuclear factor erythroid 2-related factor 2 (Nrf2) is a classical nuclear
transcription factor that regulates the system's anti-oxidative stress response. The activation …

The role of ERK1/2 pathway in the pathophysiology of Alzheimer's disease: an overview and update on new developments

MR Khezri, K Yousefi, A Esmaeili… - Cellular and molecular …, 2023 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disorder worldwide.
Several findings suggest that correcting the dysregulated signaling pathways may offer a …

Activation of Nrf2 signaling pathway by natural and synthetic chalcones: A therapeutic road map for oxidative stress

MC Egbujor, S Saha, B Buttari, E Profumo… - Expert review of clinical …, 2021 - Taylor & Francis
Introduction: Nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway plays a key
role in diverse gene expressions responsible for protection against oxidative stress and …

An overview of NRF2-activating compounds bearing α, β-unsaturated moiety and their antioxidant effects

MC Egbujor, B Buttari, E Profumo… - International Journal of …, 2022 - mdpi.com
The surge of scientific interest in the discovery of Nuclear Factor Erythroid 2 (NFE2)-Related
Factor 2 (NRF2)-activating molecules underscores the importance of NRF2 as a therapeutic …